Severe Infections in ICU: Comparing Antibiotics

We are studying whether piperacillin-tazobactam or temocillin can effectively treat severe infections caused by certain bacteria in ICU patients, compared to standard carbapenem treatment. This research may help improve treatment options for critically ill patients.

What diseases are being studied?

Health conditions and diseases that the clinical trial is designed to study and treat.

Who can participate in the clinical trial?

These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..

What medicines are being studied?

Medicines that are officially approved for use in the European Union and considered safe by EMA. These medicines are already on the market and may be tested for new conditions or populations.

Meropenem Arrow
Meropenem Arrow is an antibiotic used to treat serious bacterial infections, typically given in hospitals.

What active substances are being studied?

Active substances that are officially approved for use in the European Union and considered safe by EMA. These substances are already on the market and may be tested for new conditions or populations.

Meropenem Anhydrous
Meropenem anhydrous is an antibiotic substance used to treat severe bacterial infections by killing a wide range of bacteria.
Piperacillin
Piperacillin is an antibiotic substance used to treat serious bacterial infections, including those caused by Pseudomonas and other gram-negative bacteria.
Piperacillin Sodium
Piperacillin sodium is an antibiotic substance used to treat serious bacterial infections, including those caused by Pseudomonas.

What experimental substances are being tested?

Experimental substances that are being investigated in this clinical trial. These are not yet approved for general use.

Negaban

What similar medicines might you know?

Don't worry if you don't know the medicines tested in the trial. There is a chance you have heard about the similar medicines. Check the list below to see if you are familiar with any of them.

Agenor
Agenorem
Archifar

Where is the clinical trial being conducted?

Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.

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Centre Hospitalier Victor Dupouy
Médecine Intensive-Réanimation
Argenteuil, France
Centre Hospitalier Bethune Beuvry
Service de Médecine Intensive Réanimation
Beuvry, France
Centre Hospitalier Intercommunal De Poissy Saint Germain
Service de Médecine Intensive Réanimation
Chambourcy, France

Sponsor: Assistance Publique Hopitaux De Paris
Last updated: Nov 27, 2025

Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.