Severe Infections: MODIFY Trial

We are testing a new method to guide antibiotic treatment for severe infections, aiming to reduce unnecessary antibiotic use. This study will also evaluate how this approach impacts recovery and health outcomes.

>2 years≤5 visitsConfirmation phase (III)No PlaceboPartially RemoteStandard MedicinesInjectionInfectious DiseasesInternal Medicine

What diseases are being studied?

Health conditions and diseases that the clinical trial is designed to study and treat.

Who can participate in the clinical trial?

These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..

What medicines are being studied?

Medicines that are officially approved for use in the European Union and considered safe by EMA. These medicines are already on the market and may be tested for new conditions or populations.

Ceftazidime Kabi
Ceftazidime Kabi is an antibiotic medicine used to treat serious bacterial infections, often given by injection in hospitals.
Ceftriaxone
Ceftriaxone is an antibiotic used to treat serious bacterial infections such as pneumonia, meningitis, and severe bloodstream infections.
Cefuroxime
Cefuroxime is an antibiotic medicine used to treat common bacterial infections of the lungs, sinuses, skin, and urinary tract.

What active substances are being studied?

Active substances that are officially approved for use in the European Union and considered safe by EMA. These substances are already on the market and may be tested for new conditions or populations.

Anidulafungin
Anidulafungin is an antifungal substance used to treat serious bloodstream and invasive yeast infections.
Avibactam
Avibactam is a substance that blocks bacterial enzymes, helping certain antibiotics work against resistant Gram-negative infections.
Ceftazidime
Ceftazidime is an antibiotic substance used to treat serious bacterial infections, particularly those caused by gram-negative bacteria.

What similar medicines might you know?

Don't worry if you don't know the medicines tested in the trial. There is a chance you have heard about the similar medicines. Check the list below to see if you are familiar with any of them.

Agenor
Agenorem
Altecim

Where is the clinical trial being conducted?

Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.

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University General Hospital Of Alexandroupoli
2nd Department of Internal Medicine
Alexandroupoli, Greece
General Hospital Of Athens G Gennimatas
1st Department of Internal Medicine
Athens, Greece
Thoracic General Hospital Of Athens I Sotiria
3rd University Department of Internal Medicine
Athens, Greece
Sponsor: Hellenic Institute For The Study Of Sepsis
Last updated: Nov 27, 2025

Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.