Severe von Willebrand Disease: New Treatment Study

We are testing a new treatment for children with severe von Willebrand Disease to see if it helps control bleeding episodes and is safe during surgeries. The study will compare this treatment with and without an existing medication.

What diseases are being studied?

Health conditions and diseases that the clinical trial is designed to study and treat.

Who can participate in the clinical trial?

These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..

What medicines are being studied?

Medicines that are officially approved for use in the European Union and considered safe by EMA. These medicines are already on the market and may be tested for new conditions or populations.

Advate
Advate is a medicine used to prevent and control bleeding in people with hemophilia A.
Octagam 10%
Octagam 10% is an antibody medicine given into a vein to boost immune protection for people with antibody deficiencies or certain autoimmune conditions.
Veyvondi
Veyvondi is a medicine used to prevent and treat bleeding in people with von Willebrand disease.

What active substances are being studied?

Active substances that are officially approved for use in the European Union and considered safe by EMA. These substances are already on the market and may be tested for new conditions or populations.

Human Normal Immunoglobulin (Iv)
Human normal immunoglobulin (IV) is a substance made from donated antibodies given intravenously to boost or regulate immune function.
Octocog Alfa
Octocog alfa is a clotting factor VIII substance used to prevent and control bleeding in people with hemophilia A.
Vonicog Alfa
Vonicog alfa is a substance that helps stop and prevent bleeding in people with von Willebrand disease by replacing von Willebrand factor.

What similar medicines might you know?

Don't worry if you don't know the medicines tested in the trial. There is a chance you have heard about the similar medicines. Check the list below to see if you are familiar with any of them.

Beriglobin
Beriglobin P
Beriglobina P

Where is the clinical trial being conducted?

Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.

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Medical University Of Vienna
Department of Pediatric Cardiology / Children's Heart Center
Vienna, Austria
UZ Leuven
Hematology
Heverlee, Belgium
Centre Hospitalier Universitaire De Bordeaux
Hematology
Bordeaux, France

Sponsor: Baxalta Innovations GmbH
Last updated: Nov 26, 2025

Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.