Small-Cell Lung Cancer: Durvalumab and Olaparib Maintenance Therapy

We are studying the effects of a combination of durvalumab and olaparib for patients with HRD-positive extensive disease small-cell lung cancer after initial treatment. The goal is to see if this maintenance therapy improves outcomes and is safe for patients.

1-2 years Efficacy phase (II)No Placebo Standard Medicines Oral InjectionOncologyPulmonology

What diseases are being studied?

Health conditions and diseases that the clinical trial is designed to study and treat.

Who can participate in the clinical trial?

These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..

What medicines are being studied?

Medicines that are officially approved for use in the European Union and considered safe by EMA. These medicines are already on the market and may be tested for new conditions or populations.

Imfinzi

Imfinzi is a cancer medicine that helps the immune system find and fight tumor cells.

Lynparza

Lynparza is a cancer medicine used to treat certain ovarian, breast, pancreatic, and prostate cancers, especially those caused by specific gene changes.

What active substances are being studied?

Active substances that are officially approved for use in the European Union and considered safe by EMA. These substances are already on the market and may be tested for new conditions or populations.

Durvalumab

Durvalumab is a substance that helps the immune system recognize and attack certain cancers by blocking a protein tumors use to hide.

Olaparib

Olaparib is a substance used to treat certain cancers by blocking a DNA-repair protein so cancer cells cannot fix damage and die.

Where is the clinical trial being conducted?

Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.

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Evangelische Lungenklinik Berlin Krankenhausbetriebs gGmbH

Pneumologie

Bernau bei Berlin, Germany

Thoraxklinik Heidelberg gGmbH

Thoracic Oncology

Heidelberg, Germany

Lungenklinik Hemer Deutscher Gemeinschafts-Diakonieverband GmbH

Pneumologie

Hemer, Germany

Sponsor: University Of Cologne

Last updated: Nov 26, 2025

Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.