Small Cell Lung Cancer: Niraparib with Immunotherapy

We are studying the effects of adding niraparib to immunotherapy for patients with SLFN11-positive small cell lung cancer. This research aims to see if it improves treatment after initial therapy.

What diseases are being studied?

Health conditions and diseases that the clinical trial is designed to study and treat.

Who can participate in the clinical trial?

These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..

What medicines are being studied?

Medicines that are officially approved for use in the European Union and considered safe by EMA. These medicines are already on the market and may be tested for new conditions or populations.

Imfinzi
Imfinzi is a cancer medicine that helps the immune system find and fight tumor cells.
Tecentriq
Tecentriq is a cancer medicine that helps the immune system find and fight tumor cells.

What active substances are being studied?

Active substances that are officially approved for use in the European Union and considered safe by EMA. These substances are already on the market and may be tested for new conditions or populations.

Atezolizumab
Atezolizumab is a substance that helps the immune system recognize and attack certain cancers by blocking a protein called PD-L1.
Durvalumab
Durvalumab is a substance that helps the immune system recognize and attack certain cancers by blocking a protein tumors use to hide.
Niraparib Tosilate Monohydrate
Niraparib tosilate monohydrate is a substance that helps treat certain cancers by blocking cancer cells' ability to repair damaged DNA.

Where is the clinical trial being conducted?

Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.

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Centre Hospitalier Regional D'Angers
Medical oncology
Angers, France
Centre Hospitalier D Avignon
Medical oncology
Avignon, France
Centre Hospitalier Universitaire De Caen Normandie
Medical oncology
Caen, France

Sponsor: ETOP IBCSG Partners Foundation
Last updated: Nov 26, 2025

Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.