Small Cell Lung Cancer: Trilaciclib vs Placebo

We are studying whether trilaciclib can improve survival for patients with extensive stage small cell lung cancer receiving chemotherapy. The trial will also assess its effects on tumor response and safety compared to a placebo.

What diseases are being studied?

Health conditions and diseases that the clinical trial is designed to study and treat.

Who can participate in the clinical trial?

These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..

What medicines are being studied?

Medicines that are officially approved for use in the European Union and considered safe by EMA. These medicines are already on the market and may be tested for new conditions or populations.

Hycamtin 4 Mg Powder For Concentrate For Solution For Infusion
Hycamtin is a chemotherapy medicine used to treat certain types of cancer.
Natrium Chloratum Baxter
Natrium Chloratum Baxter is a sterile salt solution used to replace body fluids, hydrate patients, and give medicines through a vein.
Topotecan
Topotecan is a chemotherapy medicine used to treat certain cancers, including ovarian and small-cell lung cancer.

What active substances are being studied?

Active substances that are officially approved for use in the European Union and considered safe by EMA. These substances are already on the market and may be tested for new conditions or populations.

Glucose Monohydrate
Glucose monohydrate is a form of sugar used to provide quick energy and to raise low blood sugar levels.
Sodium Chloride
Sodium chloride is a substance used to replace salts and fluids in the body and to clean or irrigate wounds and nasal passages.
Sodium Chloride Solution 0.9%
Sodium chloride 0.9% is a sterile salt solution used to replace fluids and electrolytes, hydrate patients, and clean wounds or body cavities.

What experimental substances are being tested?

Experimental substances that are being investigated in this clinical trial. These are not yet approved for general use.

Trilaciclib

What similar medicines might you know?

Don't worry if you don't know the medicines tested in the trial. There is a chance you have heard about the similar medicines. Check the list below to see if you are familiar with any of them.

Acuolens
Addex Natriumklorid
Aminoplasmal E

Where is the clinical trial being conducted?

Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.

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Medical University Of Graz
Clinical Department for Lung Diseases
Graz, Austria
Klinik Hietzing
Department or Respiratory and Pulmonary Diseases
Perchtoldsdorf, Austria
Centre Hospitalier Regional De La Citadelle
Pneumology
Liège, Belgium

Sponsor: Pharmacosmos A/S
Last updated: Nov 27, 2025

Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.