Stage IV NSCLC: Osimertinib with Chemotherapy

We are studying the combination of osimertinib and chemotherapy for patients with stage IV non-small cell lung cancer who have atypical EGFR mutations. The goal is to evaluate its effectiveness, safety, and impact on quality of life.

What diseases are being studied?

Health conditions and diseases that the clinical trial is designed to study and treat.

Who can participate in the clinical trial?

These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..

What medicines are being studied?

Medicines that are officially approved for use in the European Union and considered safe by EMA. These medicines are already on the market and may be tested for new conditions or populations.

Carboplatin
Carboplatin is a chemotherapy medicine used to treat various types of cancer.
Pemetrexed
Pemetrexed is a chemotherapy medicine used to treat certain types of lung cancer and mesothelioma.
Tagrisso
Tagrisso is a cancer medicine used to treat certain non-small cell lung cancers that have specific gene changes.

What active substances are being studied?

Active substances that are officially approved for use in the European Union and considered safe by EMA. These substances are already on the market and may be tested for new conditions or populations.

Carboplatin
Carboplatin is a chemotherapy substance used to treat various cancers by damaging cancer cells and slowing tumor growth.
Cisplatin
Cisplatin is a substance used in chemotherapy to kill or stop the growth of cancer cells.
Osimertinib
Osimertinib is a targeted cancer treatment that blocks a specific protein to treat certain non-small cell lung cancers caused by gene changes.

What similar medicines might you know?

Don't worry if you don't know the medicines tested in the trial. There is a chance you have heard about the similar medicines. Check the list below to see if you are familiar with any of them.

Alimta
Armisarte
Carbo-Cell

Where is the clinical trial being conducted?

Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.

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Technische Universitaet Dresden
Medizinische Fakultät Carl Gustav Carus Medizinische Klinik I
Dresden, Germany
Krankenhaus Nordwest GmbH
Institut für Klinisch-Onkologische Forschung
Eschborn, Germany
Goethe University Frankfurt
Medizinische Klinik II
Frankfurt am Main, Germany

Sponsor: Universitat Heidelberg
Last updated: Nov 26, 2025

Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.