Myelodysplastic Syndromes (MDS)
Myelodysplastic Syndromes (MDS) are a group of disorders caused by poorly formed or dysfunctional blood cells, leading to ineffective blood production and a risk of progression to leukemia.
STOP-LEUKEMIA: Metformin for Blood Disorders
We are investigating whether metformin can help prevent leukemia in patients with clonal cytopenia of undetermined significance and lower-risk myelodysplastic syndromes. This study will assess the safety of metformin and explore how it may affect disease progression.
What diseases are being studied?
Health conditions and diseases that the clinical trial is designed to study and treat.
Clonal Cytopenia of Undetermined Significance (CCUS)
Clonal Cytopenia of Undetermined Significance (CCUS) is a condition characterized by a reduction in blood cells without a clear cause, often requiring monitoring for potential progression to more serious blood disorders.
Who can participate in the clinical trial?
These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..
- Are you between 18 and 75 years old?
- Do you have a diagnosis of diabetes or have you taken metformin in the past 3 years?
- Have you had chemotherapy or immunosuppressive therapy in the past year?
- Do you have any severe heart problems or liver issues?
- Are you currently taking any medications that suppress your immune system, like steroids?
What similar medicines might you know?
Don't worry if you don't know the medicines tested in the trial. There is a chance you have heard about the similar medicines. Check the list below to see if you are familiar with any of them.
Abmetfina Xr
Adimet
Adimet Xr
Where is the clinical trial being conducted?
Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.
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Rigshospitalet
Department of Hematology
Copenhagen, Denmark
Sponsor: Rigshospitalet
Last updated: Nov 26, 2025
Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.