Suicidal Thoughts: Nitrous Oxide Treatment in Emergencies

We are studying whether inhaling a mix of nitrous oxide and oxygen can reduce suicidal thoughts in patients at emergency departments. The trial also looks at its effects on anxiety and depression symptoms over time.

≤3 months 6-10 visits Efficacy phase (II)No Placebo Standard MedicinesPsychiatry

What diseases are being studied?

Health conditions and diseases that the clinical trial is designed to study and treat.

Who can participate in the clinical trial?

These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..

What medicines are being studied?

Medicines that are officially approved for use in the European Union and considered safe by EMA. These medicines are already on the market and may be tested for new conditions or populations.

Medical Air

Medical Air is clean, compressed air used in hospitals to help patients breathe and power breathing and surgical equipment.

Oxygen 100% V/V

Oxygen 100% V/V is medical oxygen used to increase blood oxygen in people with breathing problems or low oxygen levels.

Placynox 50% /50%

What active substances are being studied?

Active substances that are officially approved for use in the European Union and considered safe by EMA. These substances are already on the market and may be tested for new conditions or populations.

Nitrogen

Nitrogen is a substance used in liquid form to freeze and remove unwanted skin growths.

Nitrous Oxide

Nitrous oxide is a gas used to relieve pain and anxiety and produce mild sedation during dental work, childbirth, and minor procedures.

Oxygen

Oxygen is a gas used to raise blood oxygen and support breathing in people with respiratory problems or low oxygen levels.

What similar medicines might you know?

Don't worry if you don't know the medicines tested in the trial. There is a chance you have heard about the similar medicines. Check the list below to see if you are familiar with any of them.

Actynox

Where is the clinical trial being conducted?

Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.

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Centre Hospitalier Regional Universitaire De Tours

Psychiatric emergencies

Saint-Avertin, France

Sponsor: Centre Hospitalier Regional Universitaire De Tours

Last updated: Nov 27, 2025

Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.