Surgical Site Infection Prevention: Linezolid vs. Vancomycin

We are studying whether linezolid is as effective as vancomycin in preventing infections after surgery. This trial includes various surgeries and looks at infection rates and patient experiences.

>2 years≤5 visitsConfirmation phase (III)No PlaceboPartially RemoteStandard MedicinesInjectionInfectious DiseasesOrthopedics and Traumatology

What diseases are being studied?

Health conditions and diseases that the clinical trial is designed to study and treat.

Who can participate in the clinical trial?

These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..

What medicines are being studied?

Medicines that are officially approved for use in the European Union and considered safe by EMA. These medicines are already on the market and may be tested for new conditions or populations.

Linezolid Kabi
Linezolid Kabi is an antibiotic medicine used to treat serious bacterial infections like pneumonia and skin infections.
Vancomycine Hikma
Vancomycine Hikma is an antibiotic used to treat serious bacterial infections when other antibiotics don't work.
Vancomycine Mip
Vancomycine Mip is an antibiotic used to treat serious bacterial infections, including infections that don’t respond to other antibiotics.

What active substances are being studied?

Active substances that are officially approved for use in the European Union and considered safe by EMA. These substances are already on the market and may be tested for new conditions or populations.

Linezolid
Linezolid is an antibiotic substance used to treat serious Gram-positive bacterial infections, including resistant strains.
Vancomycin
Vancomycin is an antibiotic substance used to treat serious bacterial infections, including some strains resistant to other antibiotics.
Vancomycin Hydrochloride
Vancomycin hydrochloride is an antibiotic substance used to treat serious infections caused by certain bacteria that are resistant to other treatments.

What similar medicines might you know?

Don't worry if you don't know the medicines tested in the trial. There is a chance you have heard about the similar medicines. Check the list below to see if you are familiar with any of them.

Anozilad
Antizolid
Apel

Where is the clinical trial being conducted?

Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.

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Centre Hospitalier Du Pays D Aix Centre Hospitalier Intercommunal Aix-Pertuis
anesthésie-réanimation
Aix-en-Provence, France
Clinique Generale
anesthésie-réanimation
Annecy, France
CHU Gabriel-Montpied
anesthésie-réanimation
Beaumont, France
Sponsor: Assistance Publique Hopitaux De Marseille
Last updated: Nov 27, 2025

Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.