Thyroid Eye Disease: Sirolimus vs. Corticosteroids

We are comparing a new treatment called Sirolimus with corticosteroids for people with active thyroid eye disease. The goal is to see if Sirolimus is more effective and has fewer side effects.

≤3 months ≤5 visits Confirmation phase (III)No Placebo Partially Remote Standard Medicines Oral InjectionEndocrinologyOphthalmology

What diseases are being studied?

Health conditions and diseases that the clinical trial is designed to study and treat.

Who can participate in the clinical trial?

These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..

What medicines are being studied?

Medicines that are officially approved for use in the European Union and considered safe by EMA. These medicines are already on the market and may be tested for new conditions or populations.

Rapamune

Rapamune is a medicine used to help prevent the body from rejecting a transplanted kidney by lowering the immune system’s activity.

Solu-Medrol S.A.B. (= Sine Alcohol Benzylicus)

Solu‑Medrol S.A.B. is a steroid medicine used to reduce inflammation and treat severe allergic reactions, asthma attacks, and certain autoimmune conditions.

What active substances are being studied?

Active substances that are officially approved for use in the European Union and considered safe by EMA. These substances are already on the market and may be tested for new conditions or populations.

Methylprednisolone

Methylprednisolone is a corticosteroid that reduces inflammation and calms an overactive immune system.

Sirolimus

Sirolimus is a substance that suppresses the immune system to help prevent rejection after organ transplantation.

What similar medicines might you know?

Don't worry if you don't know the medicines tested in the trial. There is a chance you have heard about the similar medicines. Check the list below to see if you are familiar with any of them.

Hyftor

Lemod Solu

Lyo-Drol

Where is the clinical trial being conducted?

Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.

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Sorlandet Sykehus HF

Department of Opthalmology

Arendal, Norway

Helse Bergen HF

Department of Opthalmology

Bergen, Norway

Universitetssykehuset Nord-Norge HF

Department of Ophthalmology

Tromsø, Norway

Sponsor: Helse Bergen HF

Last updated: Nov 27, 2025

Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.