Triple Negative Breast Cancer: Atezolizumab, Vinorelbine, and Cyclophosphamide Study

We are studying a combination of three drugs to see if it can activate the immune system in patients with advanced triple negative breast cancer who have been treated with prior immunotherapy. The goal is to evaluate how well this treatment works and its safety.

What diseases are being studied?

Health conditions and diseases that the clinical trial is designed to study and treat.

Who can participate in the clinical trial?

These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..

What medicines are being studied?

Medicines that are officially approved for use in the European Union and considered safe by EMA. These medicines are already on the market and may be tested for new conditions or populations.

Tecentriq
Tecentriq is a cancer medicine that helps the immune system find and fight tumor cells.
Vinorelbine
Vinorelbine is a chemotherapy medicine used to treat certain cancers, most commonly lung and breast cancer.

What active substances are being studied?

Active substances that are officially approved for use in the European Union and considered safe by EMA. These substances are already on the market and may be tested for new conditions or populations.

Atezolizumab
Atezolizumab is a substance that helps the immune system recognize and attack certain cancers by blocking a protein called PD-L1.
Cyclophosphamide Monohydrate
Cyclophosphamide monohydrate is an anti-cancer substance used to treat various cancers and some serious autoimmune diseases.
Vinorelbine
Vinorelbine is a substance used to treat certain cancers by preventing cancer cells from dividing.

What similar medicines might you know?

Don't worry if you don't know the medicines tested in the trial. There is a chance you have heard about the similar medicines. Check the list below to see if you are familiar with any of them.

Navelbine
Vinorelbin Eugia
Vinorelbin Teva

Where is the clinical trial being conducted?

Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.

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Azienda Sanitaria Locale Br
UOC Oncologia Medica
Brindisi, Italy
Fondazione Policlinico Universitario Agostino Gemelli IRCCS
UOSD Medicina di Precisione in Senologia
La Massimina-Casal Lumbroso, Italy
Fondazione Policlinico Universitario Agostino Gemelli IRCCS
UOC Oncologia Medica
La Massimina-Casal Lumbroso, Italy

Sponsor: Istituto Europeo Di Oncologia S.r.l.
Last updated: Nov 27, 2025

Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.