Triple-Negative Breast Cancer: Keytruda with Chemotherapy

We are studying how different chemotherapy regimens combined with Keytruda affect the immune response in patients with early-stage triple-negative breast cancer. The goal is to find the most effective treatment approach for this specific cancer type.

What diseases are being studied?

Health conditions and diseases that the clinical trial is designed to study and treat.

Who can participate in the clinical trial?

These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..

What medicines are being studied?

Medicines that are officially approved for use in the European Union and considered safe by EMA. These medicines are already on the market and may be tested for new conditions or populations.

Carboplatin
Carboplatin is a chemotherapy medicine used to treat various types of cancer.
Epirubicin
Epirubicin is a chemotherapy medicine used to treat several types of cancer, especially breast cancer.
Filgrastim Hexal
Filgrastim Hexal is a medicine that boosts white blood cell production to help reduce infection risk during chemotherapy or after bone marrow transplant.

What active substances are being studied?

Active substances that are officially approved for use in the European Union and considered safe by EMA. These substances are already on the market and may be tested for new conditions or populations.

Carboplatin
Carboplatin is a chemotherapy substance used to treat various cancers by damaging cancer cells and slowing tumor growth.
Cyclophosphamide
Cyclophosphamide is a cancer-fighting and immune-suppressing substance used to treat various cancers and some severe autoimmune conditions.
Doxorubicin
Doxorubicin is a chemotherapy substance used to treat various cancers by killing rapidly dividing cancer cells.

What similar medicines might you know?

Don't worry if you don't know the medicines tested in the trial. There is a chance you have heard about the similar medicines. Check the list below to see if you are familiar with any of them.

Abutrax
Accofil
Apexelsin

Where is the clinical trial being conducted?

Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.

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Champalimaud Clinical Centre
Unidade de Mama
Belém, Portugal
Centro Hospitalar Universitario De Lisboa Norte E.P.E.
Oncologia
Campo Grande, Portugal
Instituto Portugues De Oncologia Do Porto Francisco Gentil E.P.E.
Oncologia Médica
Paranhos, Portugal
Sponsor: Champalimaud Clinical Centre
Last updated: Nov 27, 2025

Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.