Type 2 Diabetes: Comparing Empagliflozin, Pioglitazone, and Semaglutide

We are studying how different diabetes medications affect fat tissue function in people with type 2 diabetes. This research may help us understand which drug works best for improving health outcomes.

What diseases are being studied?

Health conditions and diseases that the clinical trial is designed to study and treat.

Who can participate in the clinical trial?

These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..

What medicines are being studied?

Medicines that are officially approved for use in the European Union and considered safe by EMA. These medicines are already on the market and may be tested for new conditions or populations.

Actos
Actos is a medicine that helps lower blood sugar in adults with type 2 diabetes.
Jardiance
Jardiance is a medicine that helps lower blood sugar in adults with type 2 diabetes.
Rybelsus
Rybelsus is a medicine taken by mouth to help lower blood sugar in adults with type 2 diabetes.

What active substances are being studied?

Active substances that are officially approved for use in the European Union and considered safe by EMA. These substances are already on the market and may be tested for new conditions or populations.

Canagliflozin Monohydrate
Canagliflozin monohydrate is a substance that helps lower blood sugar in people with type 2 diabetes.
Empagliflozin
Empagliflozin is a substance that helps lower blood sugar in people with type 2 diabetes by increasing sugar removal in the urine.
Pioglitazone
Pioglitazone is a substance that helps lower blood sugar by improving the body's response to insulin in people with type 2 diabetes.

What similar medicines might you know?

Don't worry if you don't know the medicines tested in the trial. There is a chance you have heard about the similar medicines. Check the list below to see if you are familiar with any of them.

Diabetalan
Empagliflozin Krka
Empagliflozin Polpharma

Where is the clinical trial being conducted?

Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.

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Aarhus University Hospital
Institute for Clinical Medicine - SDCA
Århus, Denmark
Steno Diabetes Center Copenhagen
Translational Type 2-Diabetes Research
Rødovre, Denmark
Karolinska University Hospital
ME Endokrinologi, C2-94, Karolinska Universitetssjukhuset, Huddinge
Huddinge, Sweden
Sponsor: Karolinska University Hospital
Last updated: Nov 27, 2025

Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.