Vaginal Progesterone for Fertility: Standard vs. New Formulation

We are comparing two formulations of vaginal progesterone to see which one better supports pregnancy in women undergoing fertility treatments. This study aims to improve pregnancy rates and assess safety for participants.

>2 years6-10 visitsConfirmation phase (III)No PlaceboStandard MedicinesOralEndocrinologyGynecology and Obstetrics

What diseases are being studied?

Health conditions and diseases that the clinical trial is designed to study and treat.

Who can participate in the clinical trial?

These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..

What medicines are being studied?

Medicines that are officially approved for use in the European Union and considered safe by EMA. These medicines are already on the market and may be tested for new conditions or populations.

Estradiol Besins
Estradiol Besins is a hormone medicine used to relieve menopausal symptoms like hot flashes and vaginal dryness.
Lipanthyl Micronised
Lipanthyl Micronised is a medicine used to lower high cholesterol and triglyceride levels to help reduce the risk of heart disease.
Lugesteron

What active substances are being studied?

Active substances that are officially approved for use in the European Union and considered safe by EMA. These substances are already on the market and may be tested for new conditions or populations.

Estradiol
Estradiol is a hormone used to replace low estrogen and relieve menopausal symptoms.
Estradiol Hemihydrate
Estradiol hemihydrate is a form of the female hormone estrogen used to replace low estrogen and relieve menopausal symptoms.
Fenofibrate Micronised
Fenofibrate micronised is a substance that lowers high triglycerides and cholesterol levels in the blood.

What similar medicines might you know?

Don't worry if you don't know the medicines tested in the trial. There is a chance you have heard about the similar medicines. Check the list below to see if you are familiar with any of them.

Activelle
Activelle Low
Activelle Minor

Where is the clinical trial being conducted?

Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.

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Hospital Universitari Dexeus Grupo Quironsalud
Department of Reproductive Medicine
Amorebieta, Spain
Dexeus Mujer Reus
Department of Reproductive Medicine
Reus, Spain
Hospital Universitari General De Catalunya
Department of Reproductive Medicine
Rubí, Spain
Sponsor: Santiago Dexeus Font Fundacio Privada
Last updated: Nov 27, 2025

Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.