Vertebral Metastases: Zoledronic Acid or Denosumab with Radiation

We are studying whether adding zoledronic acid or denosumab to stereotactic radiotherapy improves treatment outcomes for patients with vertebral metastases. This trial will also look at cost-effectiveness and various health impacts.

>2 years 11-15 visits Confirmation phase (III)No Placebo Standard Medicines InjectionOncology

What diseases are being studied?

Health conditions and diseases that the clinical trial is designed to study and treat.

Who can participate in the clinical trial?

These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..

What medicines are being studied?

Medicines that are officially approved for use in the European Union and considered safe by EMA. These medicines are already on the market and may be tested for new conditions or populations.

Xgeva

Xgeva is a medicine used to help prevent bone problems in people whose cancer has spread to the bones.

Zometa

Zometa is a medicine used to treat high calcium levels and help protect bones in people with cancer that has spread to bone.

What active substances are being studied?

Active substances that are officially approved for use in the European Union and considered safe by EMA. These substances are already on the market and may be tested for new conditions or populations.

Denosumab

Denosumab is a substance that helps prevent bone breakdown and strengthen bones to reduce fracture risk in osteoporosis and cancer-related bone loss.

Zoledronic Acid Monohydrate

Zoledronic acid monohydrate is a bisphosphonate that helps prevent bone loss and reduce bone complications from osteoporosis and cancer.

What similar medicines might you know?

Don't worry if you don't know the medicines tested in the trial. There is a chance you have heard about the similar medicines. Check the list below to see if you are familiar with any of them.

Acid Zoledronic Accord

Acid Zoledronic Fresenius Kabi

Acide Zoledronique Altan

Where is the clinical trial being conducted?

Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.

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CHU De Martinique

Radiotherapy

Amilly, France

Institut De Cancerologie De L Ouest

Radiotherapy

Angers, France

Institut Bergonie

Radiotherapy

Bordeaux, France

Sponsor: Institut De Cancerologie De L Ouest

Last updated: Nov 26, 2025

Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.