Search Clinical Trials in the European Union

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941-960 of 1,694 trials

Mantle Cell Lymphoma: Pirtobrutinib and Rituximab Study

We are evaluating a new treatment combining pirtobrutinib and rituximab for patients with indolent Mantle Cell Lymphoma. The study aims to determine its effectiveness and safety compared to standard therapies.

Mantle Cell Lymphoma1-2 yearsEfficacy phase (II)16-20 visitsPost-Trial Drug AccessNo PlaceboStandard MedicinesHematologyOncology

Idiopathic Bile Acid Diarrhea: Colesevelam Hydrochloride Tablet

We are studying a new tablet for patients with idiopathic bile acid diarrhea to see if it improves stool consistency compared to a placebo. The trial will also evaluate the safety and tolerability of this treatment.

Bile Acid Diarrhoea≤3 monthsEfficacy phase (II)≤5 visitsInvestigational MedicinesGastroenterologyInternal Medicine

Short Bowel Syndrome: Crofelemer Study

We are testing crofelemer to see if it helps adults with Short Bowel Syndrome and Intestinal Failure manage their symptoms better. The study will assess its safety and effectiveness compared to a placebo.

Short Bowel Syndrome and Intestinal Failure6-12 monthsEfficacy phase (II)6-10 visitsInvestigational MedicinesGastroenterologyInternal Medicine

Pneumonia in Preschool Children: Amoxicillin Study

We are investigating whether amoxicillin helps preschool children with pneumonia compared to a placebo. The study also looks at how the antibiotic affects airway bacteria and other related factors.

Community Acquired Pneumonia>2 yearsMonitoring phase (IV)Standard MedicinesPartially RemoteInfectious DiseasesPulmonology

Colorectal Cancer: STC-1010 Immunotherapy

We are studying a new immunotherapy for patients with advanced colorectal cancer that cannot be surgically removed. The trial aims to evaluate its safety and effectiveness alongside standard treatment options.

Unresectable Locally Advanced or Metastatic Colorectal CancerSafety phase (I)Efficacy phase (II)11-15 visitsNo PlaceboInvestigational MedicinesPartially RemoteGastroenterologyOncology

Gentamicin Injection for Cat Scratch Disease Lymphadenitis

We are studying whether an injection of gentamicin can improve symptoms in patients with cat scratch disease lymphadenitis compared to a placebo. This trial also looks at pain relief and lymph node changes over time.

Bartonellosis≤3 monthsConfirmation phase (III)≤5 visitsStandard MedicinesInfectious DiseasesInternal Medicine

Cancer Imaging: [18F]AlF-FAPI-74 PET/CT

We are studying a new imaging method for patients with newly diagnosed esophagogastric and pancreatic cancers. This trial aims to see if it detects cancer better than current imaging techniques.

Pancreatic CancerEsophagogastric AdenocarcinomaGastric Cancer1-2 yearsEfficacy phase (II)Confirmation phase (III)No PlaceboInvestigational MedicinesCost ReimbursementOncology

Apixaban in Short Bowel Syndrome Patients

We are studying how the blood levels of apixaban differ in patients with short bowel syndrome who require long-term IV nutrition. This research may help improve treatment strategies for these patients.

Short Bowel Syndrome>2 yearsMonitoring phase (IV)No PlaceboStandard MedicinesGastroenterologyInternal Medicine

Sleeping through Menopause: Hormone Therapy and Online Sleep Support

We are studying whether hormone therapy and a guided online sleep program can help improve sleep and mood in perimenopausal women. This trial aims to enhance mental health and overall well-being during this transition.

InsomniaClimacteric Symptoms3-6 monthsMonitoring phase (IV)≤5 visitsNo PlaceboStandard MedicinesCost ReimbursementPartially RemoteGynecology and ObstetricsPsychiatry

Colchicine for Peripheral Artery Disease

We are studying whether a low dose of colchicine can help reduce serious heart and limb problems in patients with peripheral artery disease. This research aims to improve safety and outcomes for those affected.

Peripheral Arterial Disease>2 yearsConfirmation phase (III)Investigational MedicinesCardiology

Irritable Bowel Syndrome: Symbioflor®2 Treatment

We are studying an oral treatment with living bacteria for people with diarrhea-predominant irritable bowel syndrome (IBS-D). The goal is to see if it helps reduce symptoms compared to a placebo.

Irritable Bowel Syndrome6-12 monthsMonitoring phase (IV)6-10 visitsStandard MedicinesCost ReimbursementGastroenterology

Brain Surgery Pain Management: Nerve Block Comparison

We are comparing two types of nerve blocks to see which one helps reduce pain and improve recovery for patients undergoing brain surgery. This study aims to find the best option for managing discomfort during the procedure.

Patients Undergoing Craniotomy for Supratentorial Mass>2 yearsMonitoring phase (IV)No PlaceboStandard MedicinesInternal MedicineNeurologyOtolaryngology

Colorectal Cancer: Encorafenib and Cetuximab with Pembrolizumab

We are studying a combination of medications for patients with BRAF V600E-mutant metastatic colorectal cancer. The goal is to see if this combination works better than pembrolizumab alone.

Metastatic Colorectal Cancer>2 yearsEfficacy phase (II)≤5 visitsPost-Trial Drug AccessNo PlaceboStandard MedicinesCost ReimbursementPartially RemoteOncology

Pancreatic Cancer: Digitoxin and Chemotherapy Study

We are exploring whether adding digitoxin to chemotherapy can help improve survival for patients with inoperable pancreatic cancer. The trial also looks at treatment safety and quality of life.

Pancreatic Cancer6-12 monthsEfficacy phase (II)Post-Trial Drug AccessNo PlaceboStandard MedicinesOncology

Prostate Cancer: Darolutamide Addition Study

We are studying whether adding darolutamide to standard treatment helps men with metastatic castration-resistant prostate cancer live longer without cancer progression.

Metastatic Castration-Resistant Prostate Cancer>2 yearsEfficacy phase (II)6-10 visitsPost-Trial Drug AccessNo PlaceboInvestigational MedicinesOncologyUrology

Multiple Myeloma: Etentamig and Iberdomide Study

We are investigating the safety and effects of a new treatment combining etentamig and iberdomide for patients with relapsed or refractory multiple myeloma. This study aims to find the best doses and assess how well the treatment works.

Multiple Myeloma>2 yearsSafety phase (I)Efficacy phase (II)Post-Trial Drug AccessNo PlaceboInvestigational MedicinesCost ReimbursementPartially RemoteHematologyOncology

Cognitive and Motor Function Study: Donepezil in Older Adults

We are investigating whether a medication can improve thinking and movement tasks in elderly volunteers. This study compares the effects of donepezil to a placebo on brain activity and performance.

Neurological Disorders≤3 monthsEfficacy phase (II)≤5 visitsStandard MedicinesCost ReimbursementNeurology

Metastatic Colorectal Cancer: Post-Surgery Chemotherapy Study

We are investigating whether adding chemotherapy after surgery or ablation helps improve outcomes for patients with metastatic colorectal cancer compared to just follow-up care.

Metastatic Colorectal CancerConfirmation phase (III)No PlaceboStandard MedicinesGastroenterologyOncology

Kidney Health: SGLT2 Inhibitor for Prediabetes

We are studying whether adding a new medication to lifestyle changes can help improve kidney function in people with prediabetes. This trial will help us understand its potential benefits for kidney health.

Early Stage Chronic Kidney Disease6-12 monthsMonitoring phase (IV)≤5 visitsStandard MedicinesEndocrinologyNephrology

Colorectal Polypectomy: Anticoagulation Study

We are investigating whether continuing blood-thinning medication during polypectomy is safe for patients. The goal is to see if it helps reduce the risk of blood clots during the procedure.

Patients on Anticoagulants for Colonoscopy>2 yearsMonitoring phase (IV)No PlaceboStandard MedicinesPartially RemoteGastroenterologyHematology