Search Clinical Trials in the European Union

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Confirmation phase (III)
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221-240 of 1,307 trials

Tranexamic Acid for Preventing Bleeding in Tooth Extractions

We are studying whether Tranexamic Acid Oral Solution can help reduce bleeding in patients taking blood thinners during tooth extractions. This trial aims to compare its effects with a placebo.

Bleeding from TeethConfirmation phase (III)Investigational MedicinesPartially RemoteGynecology and ObstetricsHematologyOtolaryngology

Splenic Marginal Zone Lymphoma: Rituximab with Zanubrutinib

We are comparing the effects of adding zanubrutinib to rituximab versus using rituximab alone in patients with untreated splenic marginal zone lymphoma. The goal is to see if the combination improves survival and response rates.

Splenic Marginal Zone Lymphoma>2 yearsConfirmation phase (III)11-15 visitsNo PlaceboStandard MedicinesOncology

Post-Menopausal Osteoporosis: BP16 vs. EU-Prolia

We are comparing a new treatment, BP16, to EU-Prolia for women with post-menopausal osteoporosis. The study looks at how well each treatment improves bone health and their safety.

Post-Menopausal Osteoporosis1-2 yearsConfirmation phase (III)11-15 visitsNo PlaceboStandard MedicinesCost ReimbursementPartially RemoteEndocrinologyRheumatology

Gastroparesis: Tradipitant Safety Study

We are evaluating the safety of a new medication, tradipitant, for patients with gastroparesis. The study also looks at how well it may help reduce symptoms and improve quality of life.

Gastroparesis3-6 monthsConfirmation phase (III)6-10 visitsPost-Trial Drug AccessNo PlaceboInvestigational MedicinesPartially RemoteEndocrinologyGastroenterology

Major Depressive Disorder: Lumateperone Study

We are testing lumateperone as an additional treatment for people with major depressive disorder who aren't responding well to their current antidepressants. The study will help us understand its effectiveness and safety.

Major Depressive Disorder≤3 monthsConfirmation phase (III)6-10 visitsInvestigational MedicinesCost ReimbursementPartially RemotePsychiatry

Mucopolysaccharidosis Type II: DNL310 Treatment Study

We are investigating the long-term safety and effects of DNL310 in patients with MPS II. This study looks at how well the treatment works for cognitive and physical development.

Hunter's Syndrome>2 yearsConfirmation phase (III)Post-Trial Drug AccessNo PlaceboStandard MedicinesCost ReimbursementPartially RemoteHematologyNeurology

Mild Male Factor Infertility: PKB171 Gel Study

We are testing a new intravaginal gel to see if it helps couples with mild male factor infertility achieve pregnancy. The study compares the gel's effects to a placebo over three treatment cycles.

Male Infertility6-12 monthsEfficacy phase (II)Confirmation phase (III)6-10 visitsInvestigational MedicinesPartially RemoteGynecology and ObstetricsUrology

Bimekizumab for Children with Moderate to Severe Plaque Psoriasis

We are studying how well bimekizumab works compared to ustekinumab in children and teens aged 6 to under 18 with moderate to severe plaque psoriasis. The trial will also look at safety and quality of life improvements.

Plaque PsoriasisConfirmation phase (III)Post-Trial Drug AccessStandard MedicinesAllergologyDermatology

Endometrial Cancer: Olaparib Maintenance Therapy

We are studying whether olaparib can help prevent cancer recurrence in patients with p53abn endometrial cancer after they receive chemoradiation. This trial compares olaparib treatment to observation alone.

p53abn HREC Patients Post-Surgery>2 yearsConfirmation phase (III)No PlaceboStandard MedicinesPartially RemoteGynecology and ObstetricsOncology

Cardiovascular Collapse: Vasopressor Use During Intubation

We are studying whether giving vasopressors before intubation helps prevent cardiovascular collapse in critically ill adults. This research aims to improve safety during a critical medical procedure.

Critical Illness>2 yearsConfirmation phase (III)No PlaceboStandard MedicinesCardiologyInternal Medicine

Sildenafil for Adults with Univentricular Heart Post-Fontan

We are studying whether adding sildenafil to existing treatments can improve physical performance and quality of life in adults with a univentricular heart after Fontan surgery.

Fontan Procedure and Univentricular Heart3-6 monthsConfirmation phase (III)Standard MedicinesCardiologyHematologyInternal MedicinePediatrics

Locally Advanced NSCLC: Alectinib vs. Durvalumab

We are studying whether alectinib or entrectinib is more effective than durvalumab for patients with advanced non-small cell lung cancer who have not progressed after initial treatment. The trial also looks at quality of life and safety for participants.

Non-Small Cell Lung Cancer>2 yearsConfirmation phase (III)>20 visitsNo PlaceboStandard MedicinesCost ReimbursementPartially RemoteOncology

Geographic Atrophy: Tinlarebant Treatment Study

We are exploring whether Tinlarebant can slow the growth of lesions in people with geographic atrophy and improve their vision. This study compares the new treatment to a placebo to assess its effectiveness.

Geographic Atrophy>2 yearsConfirmation phase (III)6-10 visitsInvestigational MedicinesOphthalmology

Pneumonia: TAD® Treatment Study

We are testing whether TAD®, an intravenous treatment, can help prevent heart injury in hospitalized patients with pneumonia. This study aims to evaluate its safety and effectiveness as an additional therapy.

Heart Injury from Pneumonia1-2 yearsConfirmation phase (III)≤5 visitsNo PlaceboInvestigational MedicinesPartially RemoteCardiologyInternal MedicinePulmonology

Anifrolumab for Polymyositis and Dermatomyositis

We are studying whether Anifrolumab can improve muscle strength and reduce corticosteroid use in adults with polymyositis and dermatomyositis compared to a placebo.

Polymyositis and Dermatomyositis>2 yearsConfirmation phase (III)≤5 visitsInvestigational MedicinesCost ReimbursementPartially RemoteInfectious DiseasesRheumatology

[18F]PSMA-1007 PET/CT Imaging for Prostate Cancer

We are studying how well a new imaging method detects cancer spread in patients with newly diagnosed high-risk prostate cancer. This could help improve diagnosis and treatment planning.

Prostate Cancer>2 yearsConfirmation phase (III)No PlaceboInvestigational MedicinesOncology

Botulinumtoxin A for Myofascial Pain in Temporomandibular Disorders

We are studying whether BTX injections in jaw muscles can effectively reduce pain in patients with temporomandibular disorders. This research may help improve treatment options for those suffering from this condition.

Temporomandibular DisorderConfirmation phase (III)No PlaceboStandard MedicinesOrthopedics and TraumatologyOtolaryngology

Guselkumab for Crohn's Disease Healing

We are studying whether guselkumab can help heal the intestinal wall in patients with Crohn's disease. This research aims to find out how effective it is over 48 weeks.

Crohn's Disease>2 yearsConfirmation phase (III)11-15 visitsPost-Trial Drug AccessNo PlaceboStandard MedicinesCost ReimbursementPartially RemoteGastroenterologyInternal Medicine

Hip Replacement Pain Management: Néfopam Study

We are studying the effects of néfopam on pain relief after hip replacement surgery. This trial compares its use against a placebo to see if it helps reduce the need for morphine and improves recovery.

Hip Replacement Surgery6-12 monthsConfirmation phase (III)Standard MedicinesInternal MedicineOrthopedics and Traumatology

Primary Biliary Cholangitis: Bezafibrate Treatments

We are studying the effects of two doses of bezafibrate in patients with primary biliary cholangitis who aren't responding well to current therapy. The goal is to see if these treatments can improve symptoms and liver health.

Primary Biliary Cholangitis>2 yearsConfirmation phase (III)6-10 visitsPost-Trial Drug AccessStandard MedicinesGastroenterologyHepatology