Search Clinical Trials in the European Union

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Confirmation phase (III)
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861-880 of 1,307 trials

Scabies Treatment: Testing Permethrin Cream

We are studying the effectiveness of a new higher-concentration permethrin cream for treating scabies in adults and children. The trial aims to see if this treatment works better than the standard cream and how safe it is.

Scabies>2 yearsConfirmation phase (III)No PlaceboStandard MedicinesDermatologyInfectious Diseases

RSV Vaccination in Stem Cell Transplant Recipients

We are studying two RSV vaccines to see how well they work in patients who have received stem cell transplants. The goal is to understand their immune response and effectiveness compared to healthy individuals.

Allogeneic Hematopoietic Stem Cell Transplantation≤3 monthsEfficacy phase (II)Confirmation phase (III)6-10 visitsNo PlaceboStandard MedicinesHematologyInfectious DiseasesInternal Medicine

Type 1 Diabetes: Diamyd Study

We are investigating whether the drug Diamyd can help preserve insulin production in adolescents and adults recently diagnosed with type 1 diabetes. The study will also look at the safety of Diamyd compared to a placebo.

Type 1 Diabetes>2 yearsConfirmation phase (III)6-10 visitsInvestigational MedicinesCost ReimbursementDiabetologyEndocrinology

Breast Reconstruction Surgery: Opioid-Free vs. Opioid-Based Anesthesia

We are studying the effects of opioid-free anesthesia compared to traditional opioid-based anesthesia in patients undergoing breast reconstruction surgery. This research aims to find safer pain management options.

Anesthesia during Breast Reconstruction Surgery>2 yearsConfirmation phase (III)OncologyOtolaryngology

Ventilator-Associated Pneumonia: Antimicrobial Stewardship Study

We are exploring a new method for managing antibiotics in patients with Ventilator-Associated Pneumonia in intensive care. This study aims to see if daily assessments can improve survival and reduce complications.

Ventilator Associated PneumoniaIntensive Care>2 yearsConfirmation phase (III)≤5 visitsNo PlaceboStandard MedicinesInfectious DiseasesPulmonology

Transfusion-Dependent β-Thalassemia: CTX001 Treatment

We are studying a new cell therapy for children with transfusion-dependent β-thalassemia to see if it can improve their condition and reduce the need for blood transfusions. The trial will also assess the safety of this treatment.

Transfusion-Dependent Thalassemia>2 yearsConfirmation phase (III)Post-Trial Drug AccessNo PlaceboStandard MedicinesCost ReimbursementHematologyPediatrics

Skin Cancer Treatment: The BLESS Trial

We are investigating whether reducing the dose of bleomycin in electrochemotherapy can still effectively treat skin cancers. This study aims to see if patients can benefit from less medication while achieving similar tumor response.

Skin Cancer>2 yearsConfirmation phase (III)Monitoring phase (IV)No PlaceboStandard MedicinesDermatologyOncology

Oxytocin Treatment for Autism in Children

We are studying whether multiple doses of oxytocin can improve social symptoms in children with autism and intellectual disability. The trial also looks at other behavioral changes and stress-related measurements.

Autism Spectrum Disorder6-12 monthsConfirmation phase (III)Monitoring phase (IV)≤5 visitsStandard MedicinesCost ReimbursementPartially RemotePediatricsPsychiatry

CSL889 for Sickle Cell Disease: A New Treatment

We are studying the safety and effects of CSL889 in adults and adolescents with sickle cell disease during painful vaso-occlusive crises. The goal is to see if it helps speed up recovery compared to a placebo.

Sickle Cell Anemia with Crisis≤3 monthsEfficacy phase (II)Confirmation phase (III)6-10 visitsPost-Trial Drug AccessInvestigational MedicinesPartially RemoteHematologyInternal Medicine

Multiple Sclerosis: Treatment Withdrawal Study for Older Adults

We are investigating whether stopping disease-modifying therapies is safe for people aged 55 and over with inactive relapsing-remitting multiple sclerosis. The study will help us understand its effects on relapse rates, disability, and quality of life.

Multiple Sclerosis>2 yearsConfirmation phase (III)No PlaceboInvestigational MedicinesCost ReimbursementInternal MedicineNeurology

Cataract Surgery: Clobetasol vs. Prednisolone in Young Children

We are studying a new eye treatment for inflammation after cataract surgery in children aged 0 to 3 years. The goal is to see if it is safer and more effective than the standard treatment.

Eye Inflammation and Pain>2 yearsConfirmation phase (III)≤5 visitsNo PlaceboStandard MedicinesOphthalmologyPediatrics

Preventing C. difficile Infections: Oral Vancomycin for Stem Cell Transplant Patients

We are studying if oral vancomycin can help prevent infections in patients receiving allogeneic stem cell transplants. This research aims to see if it reduces the risk of Clostridium difficile infections during their hospital stay.

Clostridium Difficile InfectionPatients Hospitalized for Allogeneic Hematopoietic Stem Cell Transplantation≤3 monthsConfirmation phase (III)Standard MedicinesPartially RemoteHematologyInfectious Diseases

Crohn’s Disease and Ulcerative Colitis: Tulisokibart Study

We are studying the long-term safety and effectiveness of tulisokibart in people with Crohn’s disease or ulcerative colitis. This research aims to see how well the treatment helps manage symptoms and achieve remission.

Crohn's DiseaseUlcerative Colitis>2 yearsConfirmation phase (III)>20 visitsPost-Trial Drug AccessInvestigational MedicinesGastroenterologyInternal Medicine

Glioblastoma Treatment: Optune with Pembrolizumab

We are testing whether adding pembrolizumab to Optune and temozolomide improves survival for newly diagnosed glioblastoma patients compared to a placebo. This study aims to understand the effectiveness and safety of this treatment combination.

Newly Diagnosed Glioblastoma>2 yearsConfirmation phase (III)Standard MedicinesOncology

Gastric Bypass Surgery: Tranexamic Acid Study

We are investigating whether giving Tranexamic acid during gastric bypass surgery helps reduce bleeding in patients with morbid obesity. This could lead to safer surgical procedures.

Morbid Obesity1-2 yearsConfirmation phase (III)No PlaceboStandard MedicinesInternal MedicineOrthopedics and Traumatology

Generalized Anxiety Disorder: MM120 Medication Study

We are testing a new oral medication, MM120, to see if it helps reduce anxiety symptoms in adults with generalized anxiety disorder. The study will also look at its effects on quality of life and sexual functioning.

Generalized Anxiety Disorder1-2 yearsConfirmation phase (III)16-20 visitsPost-Trial Drug AccessInvestigational MedicinesPartially RemotePsychiatry

COPD: Dronabinol for Breathlessness Relief

We are studying whether Dronabinol can help people with severe and very severe COPD experience less breathlessness. This trial will compare its effects against a placebo.

Chronic Obstructive Pulmonary Disease≤3 monthsEfficacy phase (II)Confirmation phase (III)Post-Trial Drug AccessStandard MedicinesInternal MedicinePulmonology

Ataxia Telangiectasia: EryDex Safety Study

We are assessing the safety and tolerability of EryDex in individuals with Ataxia Telangiectasia. Additionally, we’re exploring its potential effects on neurological symptoms.

Ataxia Telangiectasia (A-T)1-2 yearsConfirmation phase (III)Post-Trial Drug AccessNo PlaceboStandard MedicinesPartially RemoteInternal MedicineNeurology

Advanced Lung Cancer: Eftilagimod Alfa with Pembrolizumab

We are studying a new drug, eftilagimod alfa, combined with pembrolizumab and chemotherapy for patients with advanced non-small cell lung cancer. The goal is to see if this combination works better than standard treatments.

Advanced Non-Small Cell Lung Cancer>2 yearsConfirmation phase (III)Investigational MedicinesCost ReimbursementPartially RemoteOncology

Stroke Prevention: Low Dose Colchicine Study

We are investigating whether low dose colchicine can help prevent future strokes and other major vascular events in patients with a history of stroke due to atherosclerosis.

Cardiovascular Diseases>2 yearsConfirmation phase (III)6-10 visitsNo PlaceboStandard MedicinesCardiologyInternal Medicine