Search Clinical Trials in the European Union

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Confirmation phase (III)
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1001-1020 of 1,307 trials

Gout Treatment: Immediate vs. Delayed Febuxostat

We are studying whether starting febuxostat right after a gout attack helps reduce the number of gout days compared to starting it six weeks later. This trial is for individuals experiencing acute gout attacks.

Gout>2 yearsConfirmation phase (III)≤5 visitsNo PlaceboStandard MedicinesOrthopedics and TraumatologyRheumatology

Shoulder Surgery: Benzoyl Peroxide Treatment

We are studying whether applying a 5% benzoyl peroxide gel to the skin before shoulder surgery can reduce harmful bacteria. This may help lower the risk of infections in male patients undergoing the procedure.

Cutibacterium acnes Infection in Shoulder Arthroplasty>2 yearsConfirmation phase (III)No PlaceboInvestigational MedicinesDermatologyInfectious DiseasesOrthopedics and Traumatology

IVF Success: Exercise and Mediterranean Diet vs. Aspirin

We are studying whether exercise and a Mediterranean diet can improve live birth rates compared to aspirin for women undergoing in vitro fertilization. This research aims to find better ways to support fertility.

Women's Infertility>2 yearsConfirmation phase (III)6-10 visitsStandard MedicinesPartially RemoteCardiologyGynecology and Obstetrics

Mantle Cell Lymphoma: Sonrotoclax Plus Zanubrutinib

We are investigating whether the combination of sonrotoclax and zanubrutinib is more effective than a placebo with zanubrutinib for adults with relapsed or refractory mantle cell lymphoma. The study will also look at safety and how patients feel during treatment.

Relapsed or Refractory Mantle Cell LymphomaConfirmation phase (III)Investigational MedicinesOncology

Doxapram for Preterm Newborns

We are studying whether doxapram can safely reduce the risk of death and serious developmental problems in preterm newborns compared to a placebo. This research aims to improve outcomes for these vulnerable infants.

Apnea of PrematurityConfirmation phase (III)Standard MedicinesNeurologyPediatrics

Kidney Disease: VX-147 Study for APOL1 Variants

We are testing the safety and effectiveness of VX-147 in adults and children with APOL1-mediated proteinuric kidney disease. The study aims to see if this treatment can improve kidney function and reduce related health risks.

APOL1-mediated Proteinuric Kidney Disease>2 yearsEfficacy phase (II)Confirmation phase (III)11-15 visitsInvestigational MedicinesCost ReimbursementPartially RemoteNephrology

Chronic Migraine: Xeomin Injections

We are studying Xeomin injections to see if they can help reduce the number of migraine days for people with chronic migraines. This trial compares Xeomin to a placebo to evaluate its effectiveness and safety.

Chronic Migraine6-12 monthsConfirmation phase (III)11-15 visitsPost-Trial Drug AccessStandard MedicinesPartially RemoteNeurology

Lung Cancer Treatment: Adagrasib with Pembrolizumab

We are studying whether adding Adagrasib to standard chemotherapy and Pembrolizumab helps patients with advanced non-small cell lung cancer with a KRAS G12C mutation. The trial will also evaluate safety and quality of life.

Metastatic Non-small Cell Lung CancerConfirmation phase (III)16-20 visitsPost-Trial Drug AccessStandard MedicinesCost ReimbursementOncology

Plaque Psoriasis: JNJ-77242113 Study

We are assessing a new treatment for moderate to severe plaque psoriasis to see if it works better than a placebo and an existing medication. This study aims to understand its effectiveness and safety.

Plaque Psoriasis>2 yearsConfirmation phase (III)Investigational MedicinesDermatology

Episodic Migraine: Xeomin Injections

We are studying Xeomin injections to see if they can help reduce the number of migraine days for people with episodic migraines. This trial compares Xeomin to a placebo to evaluate its effectiveness and safety.

Episodic Migraine6-12 monthsConfirmation phase (III)11-15 visitsPost-Trial Drug AccessStandard MedicinesPartially RemoteNeurology

Functional Dyspepsia: Rikkunshito Study

We are investigating whether Rikkunshito can help relieve symptoms in patients with functional dyspepsia. The study also looks at how it may affect the digestive lining and overall gut function.

Functional Dyspepsia3-6 monthsConfirmation phase (III)≤5 visitsPost-Trial Drug AccessInvestigational MedicinesCost ReimbursementGastroenterologyInternal Medicine

Non-Small Cell Lung Cancer: BNT327 with Chemotherapy

We are studying the safety and effectiveness of BNT327, an investigational therapy, combined with chemotherapy for patients with non-small cell lung cancer. This trial compares it to standard treatments to see which works better.

Non-small cell lung cancer>2 yearsEfficacy phase (II)Confirmation phase (III)Post-Trial Drug AccessNo PlaceboInvestigational MedicinesCost ReimbursementOncology

Niemann-Pick Type C and GM1/GM2 Gangliosidosis: Nizubaglustat Study

We are investigating how well nizubaglustat works and its safety for children with Niemann-Pick type C disease and GM1 or GM2 gangliosidosis. This study aims to see if it can improve movement and coordination compared to a placebo.

Niemann-Pick Type C Disease and GM1/GM2 Gangliosidoses1-2 yearsConfirmation phase (III)6-10 visitsInvestigational MedicinesNeurologyPediatrics

Triple-Negative Breast Cancer: Optimizing Pembrolizumab Use

We are studying whether observing patients after surgery is as effective as continuing pembrolizumab treatment for those who responded well to initial therapy. This trial also looks at safety, quality of life, and fertility impacts.

Early Triple-Negative Breast Cancer (TNBC)6-12 monthsConfirmation phase (III)6-10 visitsNo PlaceboStandard MedicinesHematologyOncology

HIV Treatment: Comparing DOR/3TC and DTG/3TC

We are studying whether a new two-drug regimen can maintain viral suppression in people living with HIV who are currently stable on a three-drug treatment. This trial will also assess various health outcomes and side effects over time.

HIV Disease>2 yearsConfirmation phase (III)6-10 visitsNo PlaceboStandard MedicinesInfectious Diseases

Atenativ for Congenital Antithrombin Deficiency During Surgery

We are studying how Atenativ may help patients with congenital antithrombin deficiency during surgical procedures or childbirth. The trial looks at its safety, effectiveness, and how the body processes the medication.

Congenital Antithrombin Deficiency>2 yearsConfirmation phase (III)6-10 visitsNo PlaceboInvestigational MedicinesGynecology and ObstetricsHematologyInternal Medicine

Acute Kidney Injury: Angiotensin Receptor Blocker Study

We are studying whether an angiotensin receptor blocker can improve heart and kidney health in patients recovering from acute kidney injury after ICU discharge. This trial will help us understand its effects on overall health and safety.

Acute Kidney Injury>2 yearsConfirmation phase (III)≤5 visitsStandard MedicinesCardiologyInternal MedicineNephrology

Non-Small Cell Lung Cancer: MB12 vs. Keytruda

We are comparing a new treatment, MB12, to Keytruda for patients with non-small cell lung cancer. The study aims to understand differences in effectiveness and safety between the two options.

Advanced Non-Squamous Non-Small Cell Lung Cancer>2 yearsConfirmation phase (III)Oncology

Chickenpox Vaccine Safety Study for Young Children

We are evaluating the safety of a new chickenpox vaccine for healthy children aged 12 to 15 months. This study compares it with an existing vaccine when given with other routine immunizations.

Chickenpox6-12 monthsConfirmation phase (III)No PlaceboStandard MedicinesCost ReimbursementPartially RemoteInfectious DiseasesPediatrics

Chickenpox Vaccine Study for Children Aged 12 to 15 Months

We are evaluating a new chickenpox vaccine to see how well it works and its safety compared to the standard Varivax vaccine in healthy children. This study aims to ensure that the new vaccine provides a strong immune response.

Chickenpox6-12 monthsConfirmation phase (III)≤5 visitsNo PlaceboStandard MedicinesCost ReimbursementPartially RemoteInfectious DiseasesPediatrics