Search Clinical Trials in the European Union

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Confirmation phase (III)
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1201-1220 of 1,307 trials

Nebivolol for High Blood Pressure in Teens

We are studying how well Nebivolol works to lower blood pressure in adolescents with hypertension. The trial will also look at the safety of this medication during treatment.

Juvenile Hypertension6-12 monthsConfirmation phase (III)No PlaceboStandard MedicinesCardiologyInternal Medicine

Dravet Syndrome: EPX-100 Treatment Study

We are testing a new medication, EPX-100, to see if it helps children and adults with Dravet Syndrome manage their seizures better than a placebo. This study aims to find out if this treatment can be a useful addition to their current care.

Dravet Syndrome3-6 monthsConfirmation phase (III)Post-Trial Drug AccessInvestigational MedicinesNeurologyPediatrics

Glioblastoma: Dendritic Cell Immunotherapy Study

We are evaluating a new immune therapy for patients with glioblastoma to see if it improves survival and quality of life compared to standard treatments.

Glioblastoma>2 yearsEfficacy phase (II)Confirmation phase (III)No PlaceboInvestigational MedicinesOncology

Heart Failure: Empagliflozin and Dapagliflozin Study

We are investigating how two medications may improve outcomes for patients hospitalized with acute heart failure. The study looks at their effects on heart function and other health indicators.

Acute Decompensated Heart Failure>2 yearsConfirmation phase (III)≤5 visitsStandard MedicinesPartially RemoteCardiologyInternal Medicine

HIV-1 Reservoir Study: ITACO and ITACO-ATI

We are investigating how the HIV-1 virus behaves in patients with perinatal infections to find better treatment strategies. This study looks at the effects of temporarily stopping antiretroviral therapy and the immune responses involved.

Perinatal HIV InfectionConfirmation phase (III)No PlaceboStandard MedicinesInfectious Diseases

Erosive Esophagitis: Linaprazan Glurate vs. Lansoprazole

We are studying whether linaprazan glurate can heal erosive esophagitis in patients with GERD better than lansoprazole. This trial aims to evaluate the effectiveness and safety of the new treatment.

Erosive Esophagitis≤3 monthsConfirmation phase (III)≤5 visitsInvestigational MedicinesCost ReimbursementPartially RemoteGastroenterology

Apathy After Stroke: Brain Pathway Study

We are examining how cholinergic and dopaminergic systems relate to apathy in stroke patients. This study aims to understand the brain's role in apathy to improve future treatments.

ApathyStroke>2 yearsConfirmation phase (III)No PlaceboInvestigational MedicinesCost ReimbursementNeurologyPsychiatry

Insulin Eye Drops for Persistent Corneal Epithelial Defects

We are studying whether insulin eye drops can help heal persistent corneal defects better than standard treatments. This trial will also assess the safety of insulin drops and explore factors that may influence treatment success.

Persistent Corneal Epithelial Defect1-2 yearsConfirmation phase (III)No PlaceboStandard MedicinesOphthalmology

Dapansutrile Tablets for Acute Gout Flare

We are studying whether dapansutrile can reduce joint pain and other symptoms in people experiencing an acute gout flare. This trial compares the medication to a placebo to assess its effectiveness and safety.

Gout Flare≤3 monthsEfficacy phase (II)Confirmation phase (III)Investigational MedicinesInternal MedicineRheumatology

Chronic Lymphocytic Leukemia: BGB-16673 Treatment Study

We are studying a new treatment called BGB-16673 for patients with chronic lymphocytic leukemia or small lymphocytic lymphoma who have previously used other therapies. The goal is to see if it works better than current treatment options.

Chronic Lymphocytic Leukemia and Small Cell Lymphocytic Lymphoma>2 yearsConfirmation phase (III)No PlaceboInvestigational MedicinesHematologyOncology

Myasthenia Gravis: Rituximab Treatment Study

We are studying whether rituximab can help improve symptoms and quality of life for patients with generalized AChR-antibody positive Myasthenia Gravis. The trial will also assess its safety and impact on other treatments.

Generalized Myasthenia Gravis6-12 monthsConfirmation phase (III)Standard MedicinesNeurologyRheumatology

Atrial Fibrillation Prevention: Landiolol Hydrochloride

We are studying whether Landiolol hydrochloride can help prevent atrial fibrillation in patients undergoing heart surgery. This trial looks at how often this condition occurs in the days following the surgery.

Normal Heart RhythmNormal Ejection FractionBeta-blocker Use≤3 monthsConfirmation phase (III)6-10 visitsStandard MedicinesCardiologyInternal Medicine

Neurotrophic Keratopathy: RGN-259 Eye Drops

We are studying a new eye drop solution for people with Neurotrophic Keratopathy. The trial will compare its effects to a placebo to see if it improves eye health.

Neurotrophic Keratitis≤3 monthsConfirmation phase (III)6-10 visitsInvestigational MedicinesOphthalmology

Chronic Graft-Versus-Host Disease: Axatilimab Treatment Study

We are comparing a new treatment called axatilimab to the best available therapy for patients with chronic graft-versus-host disease who have not responded to previous treatments. The goal is to see if axatilimab is more effective and safer.

Chronic Graft-Versus-Host Disease>2 yearsConfirmation phase (III)16-20 visitsPost-Trial Drug AccessNo PlaceboInvestigational MedicinesCost ReimbursementPartially RemoteHematologyOncology

Ulcerative Colitis: Comparing Risankizumab and Vedolizumab

We are studying whether risankizumab is more effective and safe than vedolizumab for adults with moderate to severe ulcerative colitis who have not yet received targeted treatments.

Ulcerative Colitis1-2 yearsConfirmation phase (III)11-15 visitsPost-Trial Drug AccessNo PlaceboInvestigational MedicinesCost ReimbursementGastroenterologyInternal Medicine

Hypertension and Obesity: Orforglipron Study

We are investigating a new medication, Orforglipron, for people with hypertension who are also overweight or obese. The goal is to see if it can safely help manage their blood pressure.

High Blood Pressure1-2 yearsConfirmation phase (III)Investigational MedicinesPartially RemoteEndocrinologyInternal Medicine

Locally Advanced Rectal Cancer: NeoAspMet Trial

We are studying whether adding aspirin or metformin to standard chemotherapy improves tumor response in patients with locally advanced rectal cancer. This trial aims to see if these treatments can lead to better outcomes compared to standard care.

Locally Advanced Rectal CancerEfficacy phase (II)Confirmation phase (III)No PlaceboStandard MedicinesOncology

Chronic Heart Failure: Ferric Derisomaltose Treatment

We are studying whether ferric derisomaltose can improve heart health and reduce hospitalizations in people with iron deficiency and chronic heart failure. This trial compares it to no intravenous iron treatment.

Chronic Heart Failure1-2 yearsConfirmation phase (III)11-15 visitsInvestigational MedicinesCost ReimbursementPartially RemoteCardiologyInternal Medicine

Chronic Hepatitis Delta: Brelovitug Treatment Study

We are studying a new medication, brelovitug, for people with chronic hepatitis delta infection. The trial aims to see if it works better than waiting for treatment and to evaluate its safety.

Hepatitis D>2 yearsEfficacy phase (II)Confirmation phase (III)>20 visitsPost-Trial Drug AccessNo PlaceboInvestigational MedicinesCost ReimbursementPartially RemoteHepatology

Felzartamab for Kidney Transplant Recipients with Late Antibody-Mediated Rejection

We are studying whether felzartamab can improve outcomes for kidney transplant recipients facing late antibody-mediated rejection. This trial compares the new treatment to a placebo to assess its effectiveness and safety.

Kidney Transplant Rejection1-2 yearsConfirmation phase (III)6-10 visitsPost-Trial Drug AccessInvestigational MedicinesNephrology