Search Clinical Trials in the European Union

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1621-1640 of 1,738 trials

AL Amyloidosis: Teclistamab Treatment Study

We are investigating whether teclistamab can improve blood health in patients with previously treated AL amyloidosis. This study will also look at the treatment's safety and its effects on quality of life.

Amyloid Light-Chain Amyloidosis>2 yearsEfficacy phase (II)No PlaceboStandard MedicinesHematologyOncology

Blood Cancers: IDP-121 Treatment Study

We are testing a new medication, IDP-121, for patients with relapsed or refractory blood cancers like multiple myeloma and B-cell lymphoma. The goal is to find the best dose and see how well it helps improve patient outcomes.

Chronic Lymphocytic Leukemia (CLL)B-cell LymphomasMultiple Myeloma (MM)6-12 monthsSafety phase (I)Efficacy phase (II)6-10 visitsNo PlaceboInvestigational MedicinesHematologyOncology

Neoadjuvant Chemo-Immunotherapy for Stage III PD-L1 Positive NSCLC

We are studying a combination of tislelizumab and chemotherapy for patients with stage III PD-L1 positive lung cancer. The aim is to see if this treatment improves surgery success and survival rates.

Stage III Non-Small Cell Lung CancerEfficacy phase (II)No PlaceboStandard MedicinesPartially RemoteOncologyPulmonology

Refractory Schizophrenia: NaBen® with Clozapine

We are studying whether NaBen®, a new medication, can help adults with refractory schizophrenia who still have symptoms despite treatment with clozapine. The trial will also assess the safety of this combination therapy.

Treatment-resistant Schizophrenia≤3 monthsEfficacy phase (II)Confirmation phase (III)Investigational MedicinesCost ReimbursementPsychiatry

Cervical Dystonia: IPN10200 Treatment Study

We are studying the effects of IPN10200 on reducing symptoms of cervical dystonia in adults. This trial will help us understand if it can improve pain and disability compared to a placebo.

Cervical Dystonia6-12 monthsEfficacy phase (II)6-10 visitsInvestigational MedicinesPartially RemoteNeurologyOrthopedics and Traumatology

Non-Small Cell Lung Cancer: Cemiplimab and TEDOPI® Study

We are testing a new combination therapy for patients with non-small cell lung cancer who have not progressed after initial treatment. The goal is to see if this therapy helps clear cancer markers and improves survival compared to standard treatment.

Non-Small Cell Lung Cancer>2 yearsEfficacy phase (II)≤5 visitsNo PlaceboInvestigational MedicinesPartially RemoteOncology

Remdesivir for COVID-19 in Kidney Transplant Patients

We are studying whether a 10-day treatment with remdesivir can help kidney transplant recipients with mild or no COVID-19 symptoms avoid severe illness. The trial will also look at the safety and health outcomes of these patients.

COVID-196-12 monthsEfficacy phase (II)11-15 visitsNo PlaceboStandard MedicinesInfectious DiseasesNephrology

Systemic Lupus Erythematosus: CC-97540 CAR T Cell Therapy

We are studying a new CAR T cell therapy for people with active lupus who haven't responded to standard treatments. The goal is to see if it can improve symptoms and overall health.

Systemic Lupus ErythematosusLupus Nephritis>2 yearsEfficacy phase (II)11-15 visitsNo PlaceboInvestigational MedicinesCost ReimbursementPartially RemoteHematologyRheumatology

Psoriatic Arthritis: Lutikizumab and Risankizumab Study

We are testing the effectiveness and safety of a combination of two medications for adults with active psoriatic arthritis. This study aims to see if the combination works better than each medication alone.

Psoriatic Arthritis3-6 monthsEfficacy phase (II)No PlaceboInvestigational MedicinesInternal MedicineRheumatology

UTI Vaccine Study for Adults Aged 18-64

We are testing a new vaccine to see if it can safely prevent urinary tract infections caused by E. coli in adults, especially women. The study will compare its effectiveness to a placebo.

Urinary Tract Infections1-2 yearsSafety phase (I)Efficacy phase (II)6-10 visitsStandard MedicinesCost ReimbursementPartially RemoteInfectious DiseasesUrology

Cognitive Improvement in Down Syndrome: Bumetanide Study

We are investigating whether Bumetanide can enhance cognitive functions in children and adolescents with Down syndrome aged 10-16. This study aims to explore its effects on both thinking skills and related psychological aspects.

Down Syndrome>2 yearsEfficacy phase (II)6-10 visitsStandard MedicinesPediatricsPsychiatry

Oligometastatic Prostate Cancer: Lu-PSMA and Radiotherapy Study

We are investigating whether combining Lu-PSMA with stereotactic radiotherapy improves survival and quality of life for patients with oligometastatic prostate cancer compared to radiotherapy alone.

Metastatic Prostate Cancer3-6 monthsEfficacy phase (II)No PlaceboStandard MedicinesOncologyUrology

Sentinel Node Biopsy: ICG-99mTc-Nanoscan Tracer

We are studying a new hybrid tracer to improve the detection of sentinel nodes in cancer patients. This trial aims to see how well it works compared to traditional methods during preoperative imaging.

Melanoma and Other Head/Neck CancersEfficacy phase (II)No PlaceboStandard MedicinesOncologyOtolaryngology

Personalized Treatment for High-Risk Breast Cancer: PETREMAC Trial

We are studying how personalized therapies can improve outcomes for patients with high-risk breast cancer. The trial looks at treatment responses and aims to enhance surgical options while ensuring safety.

Breast Cancer>2 yearsEfficacy phase (II)No PlaceboInvestigational MedicinesOncology

Glioblastoma: Adding Zoledronic Acid to Treatment

We are studying whether adding zoledronic acid to standard chemotherapy can help improve survival and treatment response in patients with glioblastoma. We also want to assess its safety and tolerability.

Glioblastoma3-6 monthsEfficacy phase (II)6-10 visitsNo PlaceboStandard MedicinesPartially RemoteNeurologyOncology

Severe Asthma: Verekitug (UPB-101) Study

We are studying the long-term safety and effects of verekitug in adults with severe asthma. This research aims to see how it helps manage asthma attacks and improve breathing.

Severe Asthma1-2 yearsEfficacy phase (II)11-15 visitsPost-Trial Drug AccessInvestigational MedicinesCost ReimbursementPartially RemoteAllergologyPulmonology

Microscopic Colitis: SAR444336 Treatment Study

We are investigating a new treatment, SAR444336, for adults with microscopic colitis in remission. The study aims to see if it can effectively manage symptoms without steroids and evaluate its safety.

Microscopic Colitis6-12 monthsEfficacy phase (II)11-15 visitsInvestigational MedicinesPartially RemoteGastroenterologyInternal Medicine

Choline Chloride for Injection in Intestinal Failure

We are studying the safety and effectiveness of Choline Chloride for Injection in adolescents and adults with intestinal failure. This trial compares the treatment to a placebo to see how well it supports patients receiving long-term parenteral nutrition.

Intestinal Failure1-2 yearsEfficacy phase (II)Confirmation phase (III)16-20 visitsPost-Trial Drug AccessStandard MedicinesGastroenterologyNephrology

Alzheimer's Disease: NPI-001 Study

We are testing a new oral medication, NPI-001, for people aged 50 to 85 with Mild Cognitive Impairment or mild dementia due to Alzheimer's. The study aims to assess its safety and effects on brain health and cognitive function.

Alzheimer's Disease1-2 yearsEfficacy phase (II)11-15 visitsStandard MedicinesPartially RemoteInternal MedicineNeurology

Blood Cancer Treatment: CCS1477 Study

We are testing the safety and effects of the experimental drug CCS1477 in patients with advanced blood and bone marrow cancers. This study aims to see how well it works alone and in combination with other treatments.

Acute Myeloid Leukaemia (AML)Myelodysplastic Syndrome (MDS)Multiple Myeloma (MM)Safety phase (I)Efficacy phase (II)Post-Trial Drug AccessNo PlaceboInvestigational MedicinesHematologyOncology