CAR-T Cell Therapy: Understanding Extracellular Vesicles

We are studying how extracellular vesicles change before and after CAR-T cell treatment in patients, especially those experiencing neurotoxicity. This research may help improve patient care and treatment outcomes.

>2 yearsMonitoring phase (IV)No PlaceboInvestigational MedicinesInjectionHematologyInfectious DiseasesOncology

What diseases are being studied?

Health conditions and diseases that the clinical trial is designed to study and treat.

Who can participate in the clinical trial?

These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..

What medicines are being studied?

Medicines that are officially approved for use in the European Union and considered safe by EMA. These medicines are already on the market and may be tested for new conditions or populations.

Gadovist
Gadovist is a contrast agent used during MRI scans to help doctors get clearer images of organs, blood vessels, and tissues.
Kymriah
Kymriah is a personalized cell therapy used to treat certain types of blood cancers, including some leukemias and lymphomas.
Tecartus
Tecartus is a personalized cell therapy used to treat certain aggressive blood cancers in patients whose disease has returned or not responded to treatments.

What active substances are being studied?

Active substances that are officially approved for use in the European Union and considered safe by EMA. These substances are already on the market and may be tested for new conditions or populations.

Axicabtagene Ciloleucel
Axicabtagene ciloleucel is a substance that uses specially modified immune cells to target and kill certain B-cell blood cancers.
Brexucabtagene Autoleucel
Brexucabtagene autoleucel uses a patient’s engineered immune cells to target and help eliminate certain B‑cell blood cancers such as lymphoma and leukemia.
Gadobutrol
Gadobutrol is a contrast agent used in MRI scans to improve the visibility of blood vessels and body tissues.

What experimental substances are being tested?

Experimental substances that are being investigated in this clinical trial. These are not yet approved for general use.

Breyanzi
Abecma

What similar medicines might you know?

Don't worry if you don't know the medicines tested in the trial. There is a chance you have heard about the similar medicines. Check the list below to see if you are familiar with any of them.

Gadobutrol
Gadobutrol Novumgen
Gadovistauto

Where is the clinical trial being conducted?

Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.

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Centre Hospitalier Universitaire De Saint Etienne
Clinical hematology
Saint-Priest-en-Jarez, France
Centre Hospitalier Universitaire De Saint Etienne
Clinical hematology
Saint-Priest-en-Jarez, France
Centre Hospitalier Universitaire De Saint Etienne
Clinical hematology
Saint-Priest-en-Jarez, France
Sponsor: Centre Hospitalier Universitaire De Saint Etienne
Last updated: Nov 27, 2025

Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.