Search Clinical Trials in the European Union

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1-20 of 552 trials

Acute Heart Failure: Treatment Comparison Study

We are testing different emergency treatments for pulmonary congestion in patients with acute heart failure. The goal is to see which method helps patients feel better faster after they arrive at the hospital.

Acute Heart Failure with Pulmonary Congestion>2 yearsMonitoring phase (IV)Investigational MedicinesPartially RemoteCardiologyInternal Medicine

Cholangiocarcinoma: Comparing RFA and PDT Treatments

We are studying whether radiofrequency ablation or photodynamic therapy helps patients with cholangiocarcinoma live longer. We’ll also look at how these treatments affect quality of life and any potential side effects.

Hilar Cholangiocarcinoma>2 yearsMonitoring phase (IV)≤5 visitsNo PlaceboStandard MedicinesPartially RemoteGastroenterologyOncology

Corneal Transplantation: Optimized Immunosuppression Study

We are testing new immunosuppressive protocols for patients receiving corneal transplants to see if they can reduce eye pressure and cell loss. We also want to understand patient experiences and the cost-effectiveness of these treatments.

Corneal Graft Failure1-2 yearsMonitoring phase (IV)11-15 visitsNo PlaceboStandard MedicinesCost ReimbursementOphthalmology

Heart Attack Treatment: The Dan-DAPT Trial

We are testing a tailored blood-thinning strategy for heart attack patients at high bleeding risk. The goal is to see if this approach can lower bleeding without raising the chance of heart problems.

Heart Attack>2 yearsMonitoring phase (IV)No PlaceboInvestigational MedicinesPartially RemoteCardiologyInternal Medicine

Coronary Artery Disease Screening: Heart CT in Type 2 Diabetes

We are studying whether a heart CT scan can help find early signs of heart disease in people with type 2 diabetes. This may lead to better treatment options and improved heart health.

Type 2 DiabetesMonitoring phase (IV)No PlaceboStandard MedicinesCost ReimbursementCardiologyDiabetologyEndocrinology

Esophageal Achalasia: PPI Treatment Study

We are exploring whether routine use of a medication for acid reflux is better than using it only when needed after a procedure for esophageal achalasia. This study aims to improve treatment outcomes and quality of life for patients.

Esophageal Achalasia1-2 yearsMonitoring phase (IV)No PlaceboStandard MedicinesGastroenterologyInternal Medicine

Crohn's Disease: Comparing Biological Therapies After Surgery

We are studying two ways to start biological therapy after surgery for Crohn's disease to see which better prevents disease recurrence. This trial involves adults who have had an ileocolonic resection.

Crohn's Disease1-2 yearsMonitoring phase (IV)6-10 visitsNo PlaceboStandard MedicinesCost ReimbursementGastroenterologyInternal Medicine

Postoperative Pain Management: Genetic Testing for Tramadol

We are studying whether genetic testing can help tailor tramadol treatment for better pain relief and fewer side effects after surgery. This trial also compares tramadol with another pain medication to find the most effective option.

PharmacogeneticsTherapeutic Techniques for Acute Postoperative PainMonitoring phase (IV)≤5 visitsNo PlaceboStandard MedicinesInternal MedicineNeurologyPsychiatry

Febrile Neutropenia: SAFE Study on Short Antibiotic Treatment

We are studying whether stopping antibiotics after 3 days is as safe as continuing them longer for patients with febrile neutropenia. This research aims to find a potentially safer treatment approach for hematology patients.

Febrile Neutropenia>2 yearsMonitoring phase (IV)≤5 visitsNo PlaceboStandard MedicinesHematologyInfectious Diseases

Chronic Wet Cough in Children: The AMIC Study

We are investigating whether antibiotics can help children with chronic wet cough and how different treatment durations affect their recovery. The study also looks at the role of gut and airway bacteria in their health.

Chronic Wet Cough in Young Children6-12 monthsMonitoring phase (IV)Standard MedicinesInfectious DiseasesPulmonology

Prostate Medication and Gut Health Study

We are investigating how prostate treatments affect gut bacteria and how these bacteria may influence treatment responses in men with BPH and prostate cancer.

Prostate CancerBenign Prostate Hyperplasia>2 yearsMonitoring phase (IV)No PlaceboStandard MedicinesInternal MedicineUrology

Advanced Breast Cancer: Ribociclib Study

We are examining how well Ribociclib works for patients with advanced breast cancer and what factors may affect its effectiveness. The study also looks at quality of life and any side effects experienced during treatment.

Hormone Receptor Positive HER2 Negative Breast Cancer>2 yearsMonitoring phase (IV)11-15 visitsNo PlaceboStandard MedicinesPartially RemoteOncology

Aspirin for Preventing Preeclampsia in First-Time Pregnant Women

We are studying whether daily aspirin can help prevent preeclampsia and improve pregnancy outcomes in women who are pregnant for the first time after assisted reproductive technology. This trial compares aspirin to a placebo to see which is more effective.

Preeclampsia>2 yearsConfirmation phase (III)Monitoring phase (IV)≤5 visitsStandard MedicinesPartially RemoteGynecology and Obstetrics

Multiple Sclerosis: Rituximab vs. Ocrelizumab Study

We are comparing two treatments for relapsing-remitting multiple sclerosis to see if rituximab is as effective as ocrelizumab in preventing disease activity. This study also examines patient quality of life and other important factors.

Multiple Sclerosis1-2 yearsConfirmation phase (III)Monitoring phase (IV)6-10 visitsStandard MedicinesNeurology

COPD: Eosinophil-Guided Inhaled Corticosteroid Reduction

We are studying whether adjusting inhaled corticosteroid treatment based on eosinophil levels helps patients with severe COPD. We also want to see if low-dose Azithromycin can reduce hospital visits and improve overall health.

Chronic Obstructive Pulmonary Disease (COPD)>2 yearsMonitoring phase (IV)Standard MedicinesInternal MedicinePulmonology

Sedation in Older Critically Ill Patients: Dexmedetomidine vs. Placebo

We are studying whether early sedation with dexmedetomidine improves survival and health outcomes in patients aged 65 and older on ventilators. This trial aims to build on previous findings about sedation in critically ill patients.

Critically Ill PatientsMonitoring phase (IV)Standard MedicinesInternal MedicineOtolaryngologyPsychiatryPulmonology

Sodium Bicarbonate for Cardiac Arrest Treatment

We are studying whether sodium bicarbonate can help patients regain heart function during in-hospital cardiac arrest. The trial also looks at its effects on survival and neurological outcomes after 30 days.

In-Hospital Cardiac Arrest1-2 yearsMonitoring phase (IV)Standard MedicinesCardiology

Atrial Fibrillation: Semaglutide for Weight Control

We are studying whether a weekly injection of semaglutide helps people with obesity and atrial fibrillation achieve a normal heart rhythm. The trial also looks at how weight loss affects symptoms and quality of life.

ObesityAtrial Fibrillation1-2 yearsMonitoring phase (IV)≤5 visitsInvestigational MedicinesCardiologyEndocrinologyInternal Medicine

Fertility Treatment: Progesterone Support in IUI

We are studying if adding progesterone support helps couples with unexplained infertility achieve higher live birth rates during intra-uterine insemination. We also want to see if this approach is cost-effective and safe.

Female Infertility and Subfertility1-2 yearsMonitoring phase (IV)Investigational MedicinesEndocrinologyGynecology and Obstetrics

Corticosteroid Treatment for Acute Myocarditis

We are studying whether intravenous corticosteroids can improve heart function in patients with acute myocarditis and mildly reduced heart performance. This trial compares corticosteroid therapy to standard treatment options.

Acute Myocarditis>2 yearsConfirmation phase (III)Monitoring phase (IV)No PlaceboStandard MedicinesCardiologyInternal Medicine