Sedation in Older Critically Ill Patients: Dexmedetomidine vs. Placebo

We are studying whether early sedation with dexmedetomidine improves survival and health outcomes in patients aged 65 and older on ventilators. This trial aims to build on previous findings about sedation in critically ill patients.

Monitoring phase (IV)Standard MedicinesInjectionInternal MedicineOtolaryngologyPsychiatryPulmonology

What diseases are being studied?

Health conditions and diseases that the clinical trial is designed to study and treat.

Who can participate in the clinical trial?

These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..

What medicines are being studied?

Medicines that are officially approved for use in the European Union and considered safe by EMA. These medicines are already on the market and may be tested for new conditions or populations.

Dexmedetomidine Ever Pharma
Dexmedetomidine Ever Pharma is a medicine used to calm and sedate patients during surgery or in intensive care.

What active substances are being studied?

Active substances that are officially approved for use in the European Union and considered safe by EMA. These substances are already on the market and may be tested for new conditions or populations.

Dexmedetomidine
Dexmedetomidine is a sedative substance used to calm patients and reduce anxiety and pain during surgery or in intensive care.
Dexmedetomidine Hydrochloride
Dexmedetomidine hydrochloride is a substance that provides calming sedation to help patients stay relaxed and lightly sedated during procedures or intensive care.

What similar medicines might you know?

Don't worry if you don't know the medicines tested in the trial. There is a chance you have heard about the similar medicines. Check the list below to see if you are familiar with any of them.

Deksmedetomidin Ever Pharma
Deksmedetomidin Kabi
Deksmedetomidin Kalceks

Where is the clinical trial being conducted?

Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.

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Tampere University Hospital
Department of Anaesthesiology
Tampere, Finland
Universitaetsklinikum Essen AöR
Department of Anestiology and Intensive Care
Essen, Germany
Universitätsklinikum Leipzig AöR
Department of Anaesthesiology, Intensive Care Medicine
Leipzig, Germany

Sponsor: Monash University
Last updated: Nov 26, 2025

Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.