DENOCHARCOT Trial: DENOsumab for Charcot Foot in Diabetes

We are studying whether DENOsumab can effectively treat acute Charcot foot in people with diabetes. This trial compares the medication to a placebo to assess its impact on health outcomes.

1-2 years11-15 visitsMonitoring phase (IV)Post-Trial Drug AccessCost ReimbursementStandard MedicinesInjectionEndocrinologyOrthopedics and Traumatology

What diseases are being studied?

Health conditions and diseases that the clinical trial is designed to study and treat.

Who can participate in the clinical trial?

These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..

What medicines are being studied?

Medicines that are officially approved for use in the European Union and considered safe by EMA. These medicines are already on the market and may be tested for new conditions or populations.

Prolia
Prolia is a medicine used to strengthen bones and reduce fracture risk in people with osteoporosis.
Sodium Chloride Fresenius Kabi
Sodium Chloride Fresenius Kabi is a sterile salt solution used to replace body fluids and salts or to give medicines through a vein.

What active substances are being studied?

Active substances that are officially approved for use in the European Union and considered safe by EMA. These substances are already on the market and may be tested for new conditions or populations.

Denosumab
Denosumab is a substance that helps prevent bone breakdown and strengthen bones to reduce fracture risk in osteoporosis and cancer-related bone loss.
Sodium Chloride
Sodium chloride is a substance used to replace salts and fluids in the body and to clean or irrigate wounds and nasal passages.
Sodium Chloride Solution 0.9%
Sodium chloride 0.9% is a sterile salt solution used to replace fluids and electrolytes, hydrate patients, and clean wounds or body cavities.

What similar medicines might you know?

Don't worry if you don't know the medicines tested in the trial. There is a chance you have heard about the similar medicines. Check the list below to see if you are familiar with any of them.

Acuolens
Addex Natriumklorid
Aminoplasmal E

Where is the clinical trial being conducted?

Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.

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Aalborg University Hospital
Steno Diabetes Center North
Aalborg, Denmark
Aarhus Universitetshospital
Steno Diabetes Center Aarhus
Århus, Denmark
Bispebjerg Hospital
Department of Endocrinology
Frederiksberg, Denmark
Sponsor: Bispebjerg Hospital, Department of Endocrinology
Last updated: Nov 26, 2025

Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.