Desmoid Tumors (Aggressive Fibromatosis)
Desmoid tumors, or aggressive fibromatosis, are rare, non-cancerous tumors that develop from connective tissue, often causing pain or discomfort. They can grow aggressively and may recur after treatment.
Desmoid Tumors: Nirogacestat Study for Women
We are studying how Nirogacestat affects ovarian function in adult premenopausal women with desmoid tumors. The trial aims to understand any ovarian toxicity and the overall safety of the treatment.
What diseases are being studied?
Health conditions and diseases that the clinical trial is designed to study and treat.
Who can participate in the clinical trial?
These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..
- Are you between 18 and 40 years old?
- Are you currently pregnant or breastfeeding?
- Do you have a history of any cancer in the past 5 years, except for treated local cancers?
- Are you currently taking any medications for DT/AF, including tyrosine kinase inhibitors?
- Do you have severe liver problems?
What experimental substances are being tested?
Experimental substances that are being investigated in this clinical trial. These are not yet approved for general use.
Nirogacestat
Where is the clinical trial being conducted?
Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.
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Cliniques Universitaires Saint-Luc
Medical Oncology
Sint-Stevens-Woluwe, Belgium
Heidelberg University
Interdisciplinary Tumor Center, Universitätsklinikum Mannheim (UMM)
Mannheim, Germany
Azienda Ospedaliero-Universitaria Di Bologna IRCCS Istituto Di Ricerca E Di Cura A Carattere Scientifico
Medical Oncology
Bologna, Italy
Sponsor: Springworks Therapeutics Inc.
Last updated: Nov 27, 2025
Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.