Difficult-to-Treat Hypertension: OPTIMAL-HT Study

We are exploring whether a new combination of medications can help people with uncontrolled high blood pressure achieve better control. This study will compare different treatment strategies to find the most effective approach.

Confirmation phase (III)Monitoring phase (IV)Standard Medicines OralCardiologyInternal Medicine

What diseases are being studied?

Health conditions and diseases that the clinical trial is designed to study and treat.

Who can participate in the clinical trial?

These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..

What medicines are being studied?

Medicines that are officially approved for use in the European Union and considered safe by EMA. These medicines are already on the market and may be tested for new conditions or populations.

Elestar Hct

Elestar Hct is a medicine used to lower high blood pressure.

Espiro

Spironol

Spironol is a medicine that removes extra fluid and helps lower blood pressure in conditions like heart failure or swelling.

What active substances are being studied?

Active substances that are officially approved for use in the European Union and considered safe by EMA. These substances are already on the market and may be tested for new conditions or populations.

Amlodipine

Amlodipine is a substance that relaxes blood vessels to lower high blood pressure and help prevent chest pain (angina).

Amlodipine Besilate

Amlodipine besilate is a substance that lowers high blood pressure and relaxes blood vessels to help relieve chest pain.

Colloidal Silicon Dioxide

Colloidal silicon dioxide is a fine, porous silica used to prevent powder clumping and improve flow and stability in pills and powders.

What similar medicines might you know?

Don't worry if you don't know the medicines tested in the trial. There is a chance you have heard about the similar medicines. Check the list below to see if you are familiar with any of them.

Abesyl

Accel

Actelsar Duo Ratiopharm

Where is the clinical trial being conducted?

Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.

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Uniwersytecki Szpital Kliniczny W Bialymstoku

Klinika Chorób Wewnętrznych i Hipertensjologii

Białystok, Poland

Niepubliczny Zakład Opieki Zdrowotnej ESCULAP Tadeusz Dereziński

Gniewkowo, Poland

Centrum Diagnostyki i Leczenia Nadciśnienia Tętniczego i Cukrzycy dr n. med. Piotr Kubalski

Grudziądz, Poland

Sponsor: Narodowy Instytut Kardiologii Stefana Kardynala Wyszynskiego Panstwowy Instytut Badawczy

Last updated: Nov 26, 2025

Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.