Dopamine Changes in Depression: Escitalopram vs. Bupropion

We are studying how rewards affect dopamine levels in the brain of people with major depressive disorder compared to healthy volunteers. This trial also looks at how two different antidepressants may influence these changes.

>2 years 11-15 visits Monitoring phase (IV)No Placebo Standard Medicines OralPsychiatry

What diseases are being studied?

Health conditions and diseases that the clinical trial is designed to study and treat.

Who can participate in the clinical trial?

These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..

What medicines are being studied?

Medicines that are officially approved for use in the European Union and considered safe by EMA. These medicines are already on the market and may be tested for new conditions or populations.

Cipralex

Cipralex is a medicine used to treat depression and certain anxiety disorders by improving mood and reducing anxiety.

Wellbutrin Xr

Wellbutrin XR is a prescription medicine used to treat depression by helping improve mood and increase energy.

What active substances are being studied?

Active substances that are officially approved for use in the European Union and considered safe by EMA. These substances are already on the market and may be tested for new conditions or populations.

Bupropion Hydrochloride

Bupropion hydrochloride is a substance that treats depression and helps people quit smoking.

Escitalopram

Escitalopram is a substance that helps improve mood and reduce anxiety in people with depression or anxiety disorders.

Escitalopram Oxalate

Escitalopram oxalate is a substance that helps relieve depression and anxiety by increasing serotonin activity in the brain.

What similar medicines might you know?

Don't worry if you don't know the medicines tested in the trial. There is a chance you have heard about the similar medicines. Check the list below to see if you are familiar with any of them.

Aciprex

Amasci

Apoescitaxin Oro

Where is the clinical trial being conducted?

Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.

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Medical University Of Vienna

Department of Psychiatry and Psychotherapy, Division of General Psychiatry

Vienna, Austria

Sponsor: Medical University Of Vienna

Last updated: Nov 26, 2025

Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.