Fluid Overload in ICU: Furosemide Treatment

We are studying whether a diuretic called furosemide helps critically ill patients with fluid overload recover better than a placebo. The focus is on increasing the number of days alive and out of the hospital after 90 days.

What diseases are being studied?

Health conditions and diseases that the clinical trial is designed to study and treat.

Who can participate in the clinical trial?

These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..

What medicines are being studied?

Medicines that are officially approved for use in the European Union and considered safe by EMA. These medicines are already on the market and may be tested for new conditions or populations.

Furosemide
Furosemide is a medicine that helps the body get rid of extra water and salt to reduce swelling and lower blood pressure.

What active substances are being studied?

Active substances that are officially approved for use in the European Union and considered safe by EMA. These substances are already on the market and may be tested for new conditions or populations.

Amiloride Hydrochloride
Amiloride hydrochloride is a substance that reduces fluid buildup and helps lower high blood pressure while conserving potassium.
Furosemide
Furosemide is a substance that helps the body remove excess fluid and salt, reducing swelling and lowering blood pressure.
Furosemide Ph. Eur.
Furosemide is a substance that increases urine to remove excess fluid, commonly used for swelling and high blood pressure.

What similar medicines might you know?

Don't worry if you don't know the medicines tested in the trial. There is a chance you have heard about the similar medicines. Check the list below to see if you are familiar with any of them.

Co-Amilofruse
Co-Amilofruse Wockhardt Uk
Demefur

Where is the clinical trial being conducted?

Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.

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Fakultni Nemocnice Ostrava
Klinika anesteziologie, resuscitace a intenzivní medicíny
Hlučín, Czechia
Fakultni Nemocnice Plzen
Klinika anesteziologie, resuscitace a intenzivní medicíny
Pilsen, Czechia
Institute For Clinical And Experimental Medicine
Klinika anesteziologie, resuscitace a int. péče (KARIP)
Prague, Czechia

Sponsor: Nordsjaellands Hospital
Last updated: Nov 27, 2025

Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.