Heart Failure: Comparing Spironolactone and Eplerenone

We are studying whether spironolactone or eplerenone is more effective in reducing the risk of death for patients with heart failure. This trial is for those receiving treatment in a heart failure clinic.

>2 years Monitoring phase (IV)No Placebo Standard Medicines OralCardiologyInternal Medicine

What diseases are being studied?

Health conditions and diseases that the clinical trial is designed to study and treat.

Who can participate in the clinical trial?

These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..

What medicines are being studied?

Medicines that are officially approved for use in the European Union and considered safe by EMA. These medicines are already on the market and may be tested for new conditions or populations.

Eplerenon Stada

Eplerenon Stada is a medicine used to treat heart failure and help lower high blood pressure.

Spironolactone Accord

Spironolactone Accord is a medicine used to treat fluid buildup and high blood pressure.

What active substances are being studied?

Active substances that are officially approved for use in the European Union and considered safe by EMA. These substances are already on the market and may be tested for new conditions or populations.

Eplerenone

Eplerenone is a substance that lowers blood pressure and reduces fluid buildup to protect and improve heart function after heart failure or attack.

Spironolactone

Spironolactone is a substance that reduces fluid retention and lowers blood pressure by blocking aldosterone, also used for hormone-related acne.

What similar medicines might you know?

Don't worry if you don't know the medicines tested in the trial. There is a chance you have heard about the similar medicines. Check the list below to see if you are familiar with any of them.

Aldactacine

Aldactazide

Aldactazine

Where is the clinical trial being conducted?

Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.

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Bispebjerg Hospital

Cardiology

Frederiksberg, Denmark

Sponsor: Bispebjerg Hospital

Last updated: Nov 26, 2025

Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.