Heart Procedure: Protamine Administration Study

We are comparing routine versus selective use of protamine during transcatheter aortic valve implantation to see which method better reduces bleeding and death risks after the procedure.

≤3 monthsConfirmation phase (III)Monitoring phase (IV)Standard MedicinesInjectionCardiologyInternal Medicine

What diseases are being studied?

Health conditions and diseases that the clinical trial is designed to study and treat.

Who can participate in the clinical trial?

These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..

What medicines are being studied?

Medicines that are officially approved for use in the European Union and considered safe by EMA. These medicines are already on the market and may be tested for new conditions or populations.

Nacl 0,9 %
A 0.9% saline solution used to hydrate people, replace lost fluids, and dilute or give medicines through a vein.

What active substances are being studied?

Active substances that are officially approved for use in the European Union and considered safe by EMA. These substances are already on the market and may be tested for new conditions or populations.

Protamine Sulfate
Protamine sulfate is a substance that reverses the blood-thinning effects of heparin after surgery or overdose.
Sodium Chloride
Sodium chloride is a substance used to replace salts and fluids in the body and to clean or irrigate wounds and nasal passages.
Sodium Chloride Solution 0.9%
Sodium chloride 0.9% is a sterile salt solution used to replace fluids and electrolytes, hydrate patients, and clean wounds or body cavities.

What similar medicines might you know?

Don't worry if you don't know the medicines tested in the trial. There is a chance you have heard about the similar medicines. Check the list below to see if you are familiar with any of them.

Acuolens
Addex Natriumklorid
Aminoplasmal E

Where is the clinical trial being conducted?

Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.

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Algemeen Stedelijk Ziekenhuis Campus Aalst
Cardiology
Aalst, Belgium
UZ Leuven
Cardiology
Heverlee, Belgium
Academic Medical Center At The University Of Amsterdam
Cardiology
Abcoude, Netherlands
Sponsor: St Antonius Hospital
Last updated: Nov 27, 2025

Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.