HIV Prevention: Long-Acting Injectable Cabotegravir vs. Daily Oral Medication

We are studying whether a long-acting injectable form of cabotegravir is more effective than daily oral medication for preventing HIV in men who have sex with men. This trial aims to understand how well each option works over time and their impact on participants' health and behaviors.

>2 years11-15 visitsConfirmation phase (III)Monitoring phase (IV)No PlaceboInvestigational MedicinesOralInjectionInfectious DiseasesInternal Medicine

What diseases are being studied?

Health conditions and diseases that the clinical trial is designed to study and treat.

Who can participate in the clinical trial?

These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..

What medicines are being studied?

Medicines that are officially approved for use in the European Union and considered safe by EMA. These medicines are already on the market and may be tested for new conditions or populations.

Truvada
Truvada is a medicine used to treat and reduce the risk of HIV infection.

What active substances are being studied?

Active substances that are officially approved for use in the European Union and considered safe by EMA. These substances are already on the market and may be tested for new conditions or populations.

Cabotegravir
Cabotegravir is a substance that helps treat and prevent HIV by blocking the virus from integrating into human DNA.
Cabotegravir Sodium
Cabotegravir sodium is a long-acting antiviral substance used to treat and prevent HIV infection by stopping the virus from establishing itself in immune cells.
Emtricitabine
Emtricitabine is a substance that helps prevent and treat HIV by stopping the virus from multiplying when used with other HIV treatments.

What experimental substances are being tested?

Experimental substances that are being investigated in this clinical trial. These are not yet approved for general use.

Apretude

What similar medicines might you know?

Don't worry if you don't know the medicines tested in the trial. There is a chance you have heard about the similar medicines. Check the list below to see if you are familiar with any of them.

Atrilesto
Efatriten
Efavemten

Where is the clinical trial being conducted?

Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.

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Assistance Publique Hopitaux De Paris
Maladies Infectieuses et Tropicales
Angers, France
Assistance Publique Hopitaux De Paris
Maladies Infectieuses et Tropicales
Bagnolet, France
Assistance Publique Hopitaux De Paris
Maladies Infectieuses
Montrouge, France
Sponsor: Inserm
Last updated: Nov 26, 2025

Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.