Inflammatory Bowel Disease: Vedolizumab Dose Reduction Study

We are studying whether patients with inflammatory bowel disease can safely lower their dose of vedolizumab. This trial will help us understand the effects on health, costs, and quality of life.

What diseases are being studied?

Health conditions and diseases that the clinical trial is designed to study and treat.

Who can participate in the clinical trial?

These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..

What medicines are being studied?

Medicines that are officially approved for use in the European Union and considered safe by EMA. These medicines are already on the market and may be tested for new conditions or populations.

Entyvio
Entyvio is a medicine used to treat moderate to severe ulcerative colitis and Crohn’s disease by reducing inflammation in the gut.
Vedolix

What active substances are being studied?

Active substances that are officially approved for use in the European Union and considered safe by EMA. These substances are already on the market and may be tested for new conditions or populations.

Ibuprofen
Ibuprofen is a substance that reduces pain, fever, and inflammation.
Vedolizumab
Vedolizumab is a substance that reduces gut inflammation by blocking immune cell activity, used for treating ulcerative colitis and Crohn's disease.

What similar medicines might you know?

Don't worry if you don't know the medicines tested in the trial. There is a chance you have heard about the similar medicines. Check the list below to see if you are familiar with any of them.

200 Mg + 500 Mg
3 Months Ibuprofen Strawberry Flavour
3 Months Plus Strawberry Flavour

Where is the clinical trial being conducted?

Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.

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Amsterdam UMC
Gastroenterology
Amstelveen, Netherlands
Universitair Medisch Centrum Utrecht
Gastroenterology
De Bilt, Netherlands
UMC Groningen
Gastroenterology
Groningen, Netherlands

Sponsor: Stichting Amsterdam UMC
Last updated: Nov 27, 2025

Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.