Inflammatory Rheumatic Diseases: JAK Inhibitor Dose Reduction Study

We are exploring if lowering the dose of JAK inhibitors is as effective as keeping the current dose for patients with rheumatoid arthritis, psoriatic arthritis, or axial spondyloarthritis in low disease activity. This study will also look at safety and how many patients can successfully reduce their medication.

What diseases are being studied?

Health conditions and diseases that the clinical trial is designed to study and treat.

Who can participate in the clinical trial?

These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..

What medicines are being studied?

Medicines that are officially approved for use in the European Union and considered safe by EMA. These medicines are already on the market and may be tested for new conditions or populations.

Jyseleca
Jyseleca is a medicine used to treat moderate-to-severe rheumatoid arthritis and ulcerative colitis.
Olumiant
Olumiant is a medicine used to treat moderate to severe rheumatoid arthritis, helping reduce joint swelling and pain.
Rinvoq
Rinvoq is a medicine used to reduce inflammation and treat conditions like rheumatoid arthritis, psoriatic arthritis, and severe eczema.

What active substances are being studied?

Active substances that are officially approved for use in the European Union and considered safe by EMA. These substances are already on the market and may be tested for new conditions or populations.

Baricitinib
Baricitinib is a substance that reduces immune-driven inflammation to treat rheumatoid arthritis.
Filgotinib
Filgotinib is a substance that reduces inflammation and helps treat rheumatoid arthritis and other inflammatory joint conditions.
Tofacitinib
Tofacitinib is a substance that reduces immune system activity to treat inflammatory autoimmune conditions like rheumatoid arthritis and ulcerative colitis.

Where is the clinical trial being conducted?

Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.

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Maasstad Ziekenhuis Stichting
Reumatologie
Barendrecht, Netherlands
Medisch Spectrum Twente
Reumatologie
Enschede, Netherlands
Sint Maartenskliniek Stichting
Reumatologie
Lent, Netherlands

Sponsor: Sint Maartenskliniek Stichting
Last updated: Nov 26, 2025

Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.