Influenza Vaccination: Antibody Responses Study

We are investigating how intranasal and intramuscular flu vaccines affect antibody levels in the nose. This research may help improve future vaccination methods.

≤3 months6-10 visitsMonitoring phase (IV)No PlaceboCost ReimbursementPartially RemoteStandard MedicinesInjectionInfectious DiseasesPulmonology

What diseases are being studied?

Health conditions and diseases that the clinical trial is designed to study and treat.

Who can participate in the clinical trial?

These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..

What medicines are being studied?

Medicines that are officially approved for use in the European Union and considered safe by EMA. These medicines are already on the market and may be tested for new conditions or populations.

Fluenz Tetra
Fluenz Tetra is a nasal spray vaccine used to protect against seasonal influenza.
Vaxigrip Tetra
Vaxigrip Tetra is a vaccine used to help protect people against seasonal influenza (flu).

What active substances are being studied?

Active substances that are officially approved for use in the European Union and considered safe by EMA. These substances are already on the market and may be tested for new conditions or populations.

A/Darwin/9/2021 (H3n2) - Like Strain (A/Norway/16606/2021, Medi 355293)
A/Darwin/9/2021 (H3N2)-like strain is an influenza A virus strain used in seasonal flu vaccines to trigger a protective immune response.
A/Hong Kong/4801/2014 (H3n2)-Like Strain (A/Hong Kong/4801/2014, Nymc X-263b)
A/Hong Kong/4801/2014 (H3N2)-like strain is a vaccine component that helps the immune system build protection against H3N2 influenza.
A/Michigan/45/2015 (H1n1)pdm09-Like Strain (A/Michigan/45/2015, Nymc X-275)
A/Michigan/45/2015 (H1N1)pdm09-like strain is an influenza virus strain used in flu vaccines to help prevent H1N1 influenza infections.

What similar medicines might you know?

Don't worry if you don't know the medicines tested in the trial. There is a chance you have heard about the similar medicines. Check the list below to see if you are familiar with any of them.

Efluelda
Efluelda Stungulyf
Efluelda Tetra

Where is the clinical trial being conducted?

Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.

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Leids Universitair Medisch Centrum (LUMC)
LUCID
Leiden, Netherlands
Sponsor: Leids Universitair Medisch Centrum (LUMC)
Last updated: Nov 27, 2025

Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.