Ischemic Stroke: DOAC Intravenous Thrombolysis Trial

We are studying whether intravenous thrombolysis is more effective than standard care for patients with ischemic stroke who have recently taken direct oral anticoagulants. This research aims to improve recovery outcomes for these patients.

What diseases are being studied?

Health conditions and diseases that the clinical trial is designed to study and treat.

Who can participate in the clinical trial?

These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..

What medicines are being studied?

Medicines that are officially approved for use in the European Union and considered safe by EMA. These medicines are already on the market and may be tested for new conditions or populations.

Actilyse
Actilyse is a medicine used to dissolve dangerous blood clots in emergencies, such as certain strokes, heart attacks, and clots in the lungs.

What active substances are being studied?

Active substances that are officially approved for use in the European Union and considered safe by EMA. These substances are already on the market and may be tested for new conditions or populations.

Alteplase
Alteplase is a substance that dissolves blood clots to restore blood flow in emergencies like stroke, heart attack, or pulmonary embolism.
Tenecteplase
Tenecteplase is a clot-dissolving substance used to quickly break up dangerous blood clots and restore blood flow in heart attacks.

What experimental substances are being tested?

Experimental substances that are being investigated in this clinical trial. These are not yet approved for general use.

Metalyse

What similar medicines might you know?

Don't worry if you don't know the medicines tested in the trial. There is a chance you have heard about the similar medicines. Check the list below to see if you are familiar with any of them.

Actilyse 10
Actilyse 20
Actilyse 50

Where is the clinical trial being conducted?

Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.

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AZ Sint-Jan Brugge AV
Department of Neurology
Brugge, Belgium
HUB Hôpital Erasme
Department of Neurology
Brussels, Belgium
UZ Leuven
Department of Neurology
Heverlee, Belgium

Sponsor: Insel Gruppe AG
Last updated: Nov 27, 2025

Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.