Juvenile Idiopathic Arthritis: Biosimilar vs. Original Medications

We are studying whether switching between biosimilar and original anti-TNF medications helps children with Juvenile Idiopathic Arthritis maintain disease control. The trial will evaluate safety, effectiveness, and the occurrence of side effects.

>2 yearsMonitoring phase (IV)No PlaceboStandard MedicinesInjectionRheumatology

What diseases are being studied?

Health conditions and diseases that the clinical trial is designed to study and treat.

Who can participate in the clinical trial?

These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..

What medicines are being studied?

Medicines that are officially approved for use in the European Union and considered safe by EMA. These medicines are already on the market and may be tested for new conditions or populations.

Enbrel
Enbrel is a medicine that helps reduce immune system–caused inflammation to treat rheumatoid arthritis, psoriatic arthritis, and some types of psoriasis.
Humira
Humira is a medicine that reduces inflammation by calming the immune system to treat autoimmune conditions such as arthritis and Crohn’s disease.

What active substances are being studied?

Active substances that are officially approved for use in the European Union and considered safe by EMA. These substances are already on the market and may be tested for new conditions or populations.

Adalimumab
Adalimumab is a biologic that blocks a key inflammatory protein (TNF) to reduce inflammation in autoimmune conditions like rheumatoid arthritis and Crohn's disease.
Etanercept
Etanercept is a substance that blocks a protein involved in inflammation to treat autoimmune conditions like rheumatoid arthritis and psoriasis.

What similar medicines might you know?

Don't worry if you don't know the medicines tested in the trial. There is a chance you have heard about the similar medicines. Check the list below to see if you are familiar with any of them.

Amgevita
Amsparity
Benepali

Where is the clinical trial being conducted?

Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.

Loading map...
Ospedale Pediatrico Giovanni XXIII, AOU Consorziale Policlinico di Bari
Pediatric
Bari, Italy
Azienda Ospedaliero-Universitaria Di Bologna IRCCS Istituto Di Ricerca E Di Cura A Carattere Scientifico
Pediatric
Bologna, Italy
Azienda Socio Sanitaria Territoriale Degli Spedali Civili Di Brescia
Pediatric Immunology and Rheumatology
Brescia, Italy
Sponsor: Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico
Last updated: Nov 27, 2025

Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.