Juvenile Idiopathic Arthritis: Early Drug Withdrawal Study

We are exploring whether stopping medication early is safe and effective for children with juvenile idiopathic arthritis in remission. This study also aims to identify new biomarkers that may help predict flare-ups after treatment withdrawal.

What diseases are being studied?

Health conditions and diseases that the clinical trial is designed to study and treat.

Who can participate in the clinical trial?

These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..

What medicines are being studied?

Medicines that are officially approved for use in the European Union and considered safe by EMA. These medicines are already on the market and may be tested for new conditions or populations.

Cosentyx
Cosentyx is a medicine used to treat plaque psoriasis, psoriatic arthritis, and certain inflammatory spine conditions.
Enbrel
Enbrel is a medicine that helps reduce immune system–caused inflammation to treat rheumatoid arthritis, psoriatic arthritis, and some types of psoriasis.
Humira
Humira is a medicine that reduces inflammation by calming the immune system to treat autoimmune conditions such as arthritis and Crohn’s disease.

What active substances are being studied?

Active substances that are officially approved for use in the European Union and considered safe by EMA. These substances are already on the market and may be tested for new conditions or populations.

Abatacept
Abatacept is a substance that reduces immune system overactivity to treat autoimmune conditions such as rheumatoid arthritis.
Adalimumab
Adalimumab is a biologic that blocks a key inflammatory protein (TNF) to reduce inflammation in autoimmune conditions like rheumatoid arthritis and Crohn's disease.
Baricitinib
Baricitinib is a substance that reduces immune-driven inflammation to treat rheumatoid arthritis.

What similar medicines might you know?

Don't worry if you don't know the medicines tested in the trial. There is a chance you have heard about the similar medicines. Check the list below to see if you are familiar with any of them.

Afslamet
Afslamet
Amgevita

Where is the clinical trial being conducted?

Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.

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Antwerp University Hospital
Pediatrics
Wilrijk, Belgium
Fakultni Nemocnice V Motole
Paediatric Department
Stodůlky, Czechia
Aarhus Universitetshospital
Pediatric rheumatology unit
Århus, Denmark

Sponsor: IRCCS Istituto Giannina Gaslini
Last updated: Nov 26, 2025

Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.