Knee Replacement Surgery: Local Anesthetic Comparison

We are studying whether using 20 mL of local anesthetic instead of 10 mL during a nerve block can reduce opioid use and improve pain management after knee surgery.

≤3 monthsMonitoring phase (IV)No PlaceboStandard MedicinesInternal MedicineOrthopedics and TraumatologyOtolaryngology

What diseases are being studied?

Health conditions and diseases that the clinical trial is designed to study and treat.

Who can participate in the clinical trial?

These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..

What active substances are being studied?

Active substances that are officially approved for use in the European Union and considered safe by EMA. These substances are already on the market and may be tested for new conditions or populations.

Bupivacaine
Bupivacaine is a local anesthetic used to numb specific areas for surgery or pain relief during and after procedures.
Bupivacaine Hydrochloride
Bupivacaine hydrochloride is a local anesthetic used to numb specific body areas for surgery or pain relief.

Where is the clinical trial being conducted?

Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.

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Regionshospitalet Silkeborg
Elective Surgery Centre
Silkeborg, Denmark
Sponsor: Region Midtjylland
Last updated: Nov 26, 2025

Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.