Liver Transplant: Single vs. Twice Daily Immunosuppressive Doses

We are studying whether a single daily dose of immunosuppressive medication is as effective as a twice-daily dose for liver transplant recipients. This trial also compares two different formulations of tacrolimus to see which works better.

>2 years Monitoring phase (IV)No Placebo Standard Medicines OralHepatologyInternal Medicine

What diseases are being studied?

Health conditions and diseases that the clinical trial is designed to study and treat.

Who can participate in the clinical trial?

These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..

What medicines are being studied?

Medicines that are officially approved for use in the European Union and considered safe by EMA. These medicines are already on the market and may be tested for new conditions or populations.

Advagraf

Advagraf is a medicine used to prevent organ rejection in people who have received a kidney, liver, or heart transplant.

Cellcept

Cellcept is a medicine that helps prevent a transplanted organ from being rejected by the immune system.

Envarsus

Envarsus is a medicine used to help prevent the body from rejecting a transplanted kidney.

What active substances are being studied?

Active substances that are officially approved for use in the European Union and considered safe by EMA. These substances are already on the market and may be tested for new conditions or populations.

Mycophenolate Mofetil

Mycophenolate mofetil is a substance that suppresses the immune system to prevent organ transplant rejection and treat autoimmune conditions.

Tacrolimus

Tacrolimus is a substance that suppresses the immune system to prevent organ transplant rejection and treat certain inflammatory conditions like severe eczema.

Tacrolimus Monohydrate

Tacrolimus monohydrate is a substance that suppresses the immune system to prevent organ transplant rejection and treat severe inflammatory skin conditions.

What similar medicines might you know?

Don't worry if you don't know the medicines tested in the trial. There is a chance you have heard about the similar medicines. Check the list below to see if you are familiar with any of them.

Adoport

Adport

Where is the clinical trial being conducted?

Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.

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CHU Besancon

hépatologie

Besançon, France

Hopital De La Croix Rousse

Hépato Gastroentérologie

Caluire-et-Cuire, France

Centre Hospitalier Universitaire De Bordeaux

service Hépato-Gastroentérologie et oncologie digestive

Canéjan, France

Sponsor: Centre Hospitalier Universitaire De Limoges

Last updated: Nov 27, 2025

Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.