Opioid-Induced Respiratory Depression: Naloxone and Nalmefene Study

We are studying how well naloxone and nalmefene can reverse breathing problems caused by opioids in both new and long-term users. This research aims to improve treatment options for respiratory depression in real-life settings.

>2 years Monitoring phase (IV)No Placebo Cost Reimbursement Investigational Medicines InjectionCardiologyInternal MedicineOtolaryngologyPulmonology

What diseases are being studied?

Health conditions and diseases that the clinical trial is designed to study and treat.

Who can participate in the clinical trial?

These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..

What medicines are being studied?

Medicines that are officially approved for use in the European Union and considered safe by EMA. These medicines are already on the market and may be tested for new conditions or populations.

Fentanyl Hameln

Fentanyl Hameln is a strong painkiller used to treat severe pain in people who need powerful, fast-acting pain relief.

Naloxon Hcl Hameln

Naloxon Hcl Hameln is an emergency medicine that quickly reverses opioid overdoses and helps restore normal breathing.

Narcan

Narcan is a nasal spray used to quickly reverse opioid overdoses and restore normal breathing in an emergency.

What active substances are being studied?

Active substances that are officially approved for use in the European Union and considered safe by EMA. These substances are already on the market and may be tested for new conditions or populations.

Anhydrous Naloxone Hydrochloride

Anhydrous naloxone hydrochloride is a substance that quickly reverses opioid overdose and restores breathing.

Fentanyl Citrate

Fentanyl citrate is a potent opioid substance used to relieve severe pain, especially during surgery or for cancer-related pain.

Nalmefene

Nalmefene is a substance that blocks opioid receptors to help reduce alcohol cravings and lower drinking in people with alcohol dependence.

What experimental substances are being tested?

Experimental substances that are being investigated in this clinical trial. These are not yet approved for general use.

Sufentanil

What similar medicines might you know?

Don't worry if you don't know the medicines tested in the trial. There is a chance you have heard about the similar medicines. Check the list below to see if you are familiar with any of them.

Abfentiq

Atossa

Avaric

Where is the clinical trial being conducted?

Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.

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Leids Universitair Medisch Centrum (LUMC)

Anesthesiology

Leiden, Netherlands

Sponsor: Leids Universitair Medisch Centrum (LUMC)

Last updated: Nov 27, 2025

Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.