Pancreas and Kidney Transplant: Sirolimus vs. Mycophenolate Mofetil

We are comparing two medications to see which one may reduce the risk of hernias after simultaneous pancreas and kidney transplants in people with type 1 diabetes. We also want to understand their effects on diabetes complications.

>2 years6-10 visitsMonitoring phase (IV)No PlaceboStandard MedicinesOralGastroenterologyInternal MedicineNephrologyOncologyUrology

What diseases are being studied?

Health conditions and diseases that the clinical trial is designed to study and treat.

Who can participate in the clinical trial?

These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..

What medicines are being studied?

Medicines that are officially approved for use in the European Union and considered safe by EMA. These medicines are already on the market and may be tested for new conditions or populations.

Rapamune
Rapamune is a medicine used to help prevent the body from rejecting a transplanted kidney by lowering the immune system’s activity.

What active substances are being studied?

Active substances that are officially approved for use in the European Union and considered safe by EMA. These substances are already on the market and may be tested for new conditions or populations.

Mycophenolate Mofetil
Mycophenolate mofetil is a substance that suppresses the immune system to prevent organ transplant rejection and treat autoimmune conditions.
Sirolimus
Sirolimus is a substance that suppresses the immune system to help prevent rejection after organ transplantation.

What similar medicines might you know?

Don't worry if you don't know the medicines tested in the trial. There is a chance you have heard about the similar medicines. Check the list below to see if you are familiar with any of them.

Hyftor

Where is the clinical trial being conducted?

Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.

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Institute For Clinical And Experimental Medicine
Diabetes
Prague, Czechia
Sponsor: Institute For Clinical And Experimental Medicine
Last updated: Nov 26, 2025

Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.