Parkinson's Disease: Safinamide vs. Rasagiline for Fatigue

We are studying whether Safinamide or Rasagiline can help reduce fatigue in people with Parkinson's Disease already on stable treatment. The trial will also monitor safety and side effects over six months.

3-6 monthsMonitoring phase (IV)No PlaceboPartially RemoteStandard MedicinesOralNeurology

What diseases are being studied?

Health conditions and diseases that the clinical trial is designed to study and treat.

Who can participate in the clinical trial?

These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..

What medicines are being studied?

Medicines that are officially approved for use in the European Union and considered safe by EMA. These medicines are already on the market and may be tested for new conditions or populations.

Rasagiline
Rasagiline is a medicine used to treat symptoms of Parkinson’s disease.
Safinamide Ab

What active substances are being studied?

Active substances that are officially approved for use in the European Union and considered safe by EMA. These substances are already on the market and may be tested for new conditions or populations.

Rasagiline
Rasagiline is a substance used to treat symptoms of Parkinson's disease by boosting dopamine activity in the brain.
Safinamide
Safinamide is a substance that helps reduce motor fluctuations and improve movement control in people with Parkinson's disease.
Safinamide Methanesulfonate
Safinamide methanesulfonate is a substance that helps control movement symptoms and reduce motor fluctuations in people with Parkinson's disease.

What similar medicines might you know?

Don't worry if you don't know the medicines tested in the trial. There is a chance you have heard about the similar medicines. Check the list below to see if you are familiar with any of them.

Altina
Anaxira
Asanix

Where is the clinical trial being conducted?

Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.

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Complexo Hospitalario Universitario A Coruna
Neurología
A Coruña, Spain
Hospital Universitari Dexeus Grupo Quironsalud
Neurología
Amorebieta, Spain
Hospital Universitario De Cruces
Neurology
Barakaldo, Spain
Sponsor: Fundacio Institut De Recerca De L Hospital De La Santa Creu I Sant Pau
Last updated: Nov 27, 2025

Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.