PCOS Fertility: Letrozole vs. Gonadotropins

We are studying whether continuing ovulation induction with letrozole is more effective than switching to gonadotropins for women with polycystic ovary syndrome. The trial also looks at safety, quality of life, and costs related to fertility treatment.

1-2 years Monitoring phase (IV)No Placebo Partially Remote Standard Medicines Oral InjectionEndocrinologyGynecology and ObstetricsInternal Medicine

What diseases are being studied?

Health conditions and diseases that the clinical trial is designed to study and treat.

Who can participate in the clinical trial?

These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..

What medicines are being studied?

Medicines that are officially approved for use in the European Union and considered safe by EMA. These medicines are already on the market and may be tested for new conditions or populations.

Letrozole

Letrozole is a medicine used to treat certain breast cancers in women after menopause by lowering hormones that can fuel tumor growth.

Menopur

Menopur is a fertility medicine used to stimulate the ovaries to produce eggs for assisted reproductive treatments like IVF.

What active substances are being studied?

Active substances that are officially approved for use in the European Union and considered safe by EMA. These substances are already on the market and may be tested for new conditions or populations.

Choriogonadotropin Alfa

Choriogonadotropin alfa is a substance that triggers ovulation and supports fertility treatments by mimicking a natural reproductive hormone.

Follitropin Alfa

Follitropin alfa is a lab-made hormone that stimulates the ovaries to develop eggs for fertility treatments.

Human Chorionic Gonadotropin

Human chorionic gonadotropin is a hormone that helps trigger ovulation and supports fertility treatments in women and reproductive function in men.

What similar medicines might you know?

Don't worry if you don't know the medicines tested in the trial. There is a chance you have heard about the similar medicines. Check the list below to see if you are familiar with any of them.

Aletro

Allenda

Aromek

Where is the clinical trial being conducted?

Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.

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Jeroen Bosch Ziekenhuis Stichting

Obstetrics & Gynecology

's-Hertogenbosch, Netherlands

Amsterdam UMC Stichting

Obstetrics & Gynecology

Abcoude, Netherlands

Noordwest Ziekenhuisgroep Stichting

Obstetrics & Gynecology

Alkmaar, Netherlands

Sponsor: Amsterdam UMC Stichting

Last updated: Nov 26, 2025

Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.