Preventing Opioid-Induced Constipation in Advanced Cancer Patients

We are comparing two laxatives to see which one better prevents constipation in patients with advanced cancer starting opioid pain treatment. This study will also assess quality of life and side effects.

≤3 months Confirmation phase (III)Monitoring phase (IV)No Placebo Standard Medicines OralInternal MedicineOncology

What diseases are being studied?

Health conditions and diseases that the clinical trial is designed to study and treat.

Who can participate in the clinical trial?

These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..

What medicines are being studied?

Medicines that are officially approved for use in the European Union and considered safe by EMA. These medicines are already on the market and may be tested for new conditions or populations.

Magnesiumhydroxide Teva

Magnesiumhydroxide Teva is a medicine that relieves constipation and soothes heartburn or upset stomach.

Movicolon Naturel

Movicolon Naturel is a medicine used to relieve constipation by softening stools and making bowel movements easier.

What active substances are being studied?

Active substances that are officially approved for use in the European Union and considered safe by EMA. These substances are already on the market and may be tested for new conditions or populations.

Macrogol 3350

Macrogol 3350 is a substance that helps soften stools and relieve constipation by drawing water into the bowel.

Magnesium Hydroxide

Magnesium hydroxide is a substance that relieves constipation and neutralizes excess stomach acid.

Potassium Chloride

Potassium chloride is a substance used to restore low potassium levels in the body and support normal heart and muscle function.

What similar medicines might you know?

Don't worry if you don't know the medicines tested in the trial. There is a chance you have heard about the similar medicines. Check the list below to see if you are familiar with any of them.

Accusol 35

Accusol 35 Kalium

Accusol 35 Potassium

Where is the clinical trial being conducted?

Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.

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Jeroen Bosch Ziekenhuis Stichting

Medische Oncologie

's-Hertogenbosch, Netherlands

Flevoziekenhuis Stichting

Oncologie

Almere Stad, Netherlands

Amsterdam UMC Stichting

Medical Oncology

Amstelveen, Netherlands

Sponsor: Amsterdam UMC

Last updated: Nov 26, 2025

Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.