Reducing Complications After Pancreatoduodenectomy: HOP Bundle Study

We are investigating whether a combination of hydrocortisone, octreotide, and a teres ligament patch can help prevent major complications in patients undergoing high-risk pancreatoduodenectomy. This study also looks at its effect on specific complications like pancreatic fistulas.

3-6 monthsMonitoring phase (IV)No PlaceboStandard MedicinesInjectionInternal MedicineOncologyOrthopedics and Traumatology

What diseases are being studied?

Health conditions and diseases that the clinical trial is designed to study and treat.

Who can participate in the clinical trial?

These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..

What medicines are being studied?

Medicines that are officially approved for use in the European Union and considered safe by EMA. These medicines are already on the market and may be tested for new conditions or populations.

Octreotide Lyomark
Octreotide Lyomark is a medicine used to control symptoms from certain hormone-secreting tumors and conditions like acromegaly.
Solu-Cortef
Solu-Cortef is a steroid medicine used to reduce inflammation and treat severe allergic reactions and adrenal gland problems.

What active substances are being studied?

Active substances that are officially approved for use in the European Union and considered safe by EMA. These substances are already on the market and may be tested for new conditions or populations.

Hydrocortisone
Hydrocortisone is a substance that reduces inflammation and calms overactive immune responses for conditions like rashes, allergies, and eczema.
Hydrocortisone Sodium Succinate
Hydrocortisone sodium succinate is a corticosteroid that reduces inflammation, treats severe allergic reactions, and replaces low adrenal hormones.
Octreotide Acetate
Octreotide acetate is a synthetic hormone-like substance that reduces excess hormone secretion to treat acromegaly and control symptoms from hormone-secreting tumors.

What similar medicines might you know?

Don't worry if you don't know the medicines tested in the trial. There is a chance you have heard about the similar medicines. Check the list below to see if you are familiar with any of them.

Abix
Acecort
Actocortina

Where is the clinical trial being conducted?

Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.

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HUS-Yhtymae
Gastroenterological Surgery / Transplantation and Liver Surgery
Helsinki, Finland
Azienda Ospedaliera di Padova
HPB Surgery and Liver Transplant
Padova, Italy
Azienda Ospedaliera Universitaria Integrata Verona
General and Pancreatic Surgery Department
Verona, Italy

Sponsor: Amsterdam UMC Stichting
Last updated: Nov 26, 2025

Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.