Relapsing Multiple Sclerosis: Rituximab vs. Ocrelizumab

We are studying whether rituximab is as effective as ocrelizumab for treating relapsing MS. This trial is for patients who are starting anti-CD20 therapy.

What diseases are being studied?

Health conditions and diseases that the clinical trial is designed to study and treat.

Who can participate in the clinical trial?

These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..

What medicines are being studied?

Medicines that are officially approved for use in the European Union and considered safe by EMA. These medicines are already on the market and may be tested for new conditions or populations.

Mabthera
Mabthera is a medicine used to treat certain blood cancers and some autoimmune diseases by targeting problematic immune cells.
Ocrevus
Ocrevus is a medicine used to treat multiple sclerosis, helping reduce relapses and slow progression of disability.
Rixathon
Rixathon is a medicine used to treat certain blood cancers and autoimmune diseases by targeting and reducing specific immune cells.

What active substances are being studied?

Active substances that are officially approved for use in the European Union and considered safe by EMA. These substances are already on the market and may be tested for new conditions or populations.

Ocrelizumab
Ocrelizumab is a substance used to treat multiple sclerosis by targeting specific immune cells to reduce inflammation and nerve damage.
Rituximab
Rituximab is a substance that targets and reduces B cells, a type of white blood cell, to treat some blood cancers and autoimmune conditions.

What similar medicines might you know?

Don't worry if you don't know the medicines tested in the trial. There is a chance you have heard about the similar medicines. Check the list below to see if you are familiar with any of them.

Blitzima
Blitzima
Blitzima

Where is the clinical trial being conducted?

Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.

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Jeroen Bosch Ziekenhuis Stichting
Neurology
's-Hertogenbosch, Netherlands
Noordwest Ziekenhuisgroep Stichting
Neurology
Alkmaar, Netherlands
Flevoziekenhuis Stichting
Neurology
Almere Stad, Netherlands

Sponsor: Amsterdam UMC
Last updated: Nov 27, 2025

Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.