Rheumatoid Arthritis: MethMax Trial

We are studying how well methotrexate works for people with active rheumatoid arthritis. The goal is to see if it helps more patients reach remission or low disease activity compared to current treatments.

3-6 months 6-10 visits Monitoring phase (IV)No Placebo Standard Medicines Oral InjectionInternal MedicineRheumatology

What diseases are being studied?

Health conditions and diseases that the clinical trial is designed to study and treat.

Who can participate in the clinical trial?

These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..

What medicines are being studied?

Medicines that are officially approved for use in the European Union and considered safe by EMA. These medicines are already on the market and may be tested for new conditions or populations.

Ebetrexat

Ebetrexat is a medicine used to treat certain cancers and autoimmune conditions like rheumatoid arthritis and psoriasis.

What active substances are being studied?

Active substances that are officially approved for use in the European Union and considered safe by EMA. These substances are already on the market and may be tested for new conditions or populations.

Methotrexate

Methotrexate is a substance that slows rapid cell growth and calms the immune system to treat certain cancers and autoimmune conditions.

Methotrexate Disodium

Methotrexate disodium is a substance that slows cell growth and suppresses the immune system to treat certain cancers and autoimmune conditions.

What similar medicines might you know?

Don't worry if you don't know the medicines tested in the trial. There is a chance you have heard about the similar medicines. Check the list below to see if you are familiar with any of them.

Bertanel

Ebetrex

Metex

Where is the clinical trial being conducted?

Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.

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Medical University of Vienna

Division of Rheumatology

Vienna, Austria

Humanitas Mirasole S.p.A.

Division of Rheumatology and Clinical Immunology

Rozzano, Italy

Academisch Ziekenhuis Leiden

Department of Rheumatology

Leiden, Netherlands

Sponsor: Medical University of Vienna

Last updated: Nov 26, 2025

Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.