Rheumatoid Arthritis: Targeted Therapy vs. Triple Therapy

We are studying whether targeted therapies are more effective than a combination of three other medications for patients with rheumatoid arthritis who haven't responded to standard treatments. The trial also looks at safety and quality of life.

≤5 visits Confirmation phase (III)Monitoring phase (IV)No Placebo Standard Medicines Oral InjectionInternal MedicineRheumatology

What diseases are being studied?

Health conditions and diseases that the clinical trial is designed to study and treat.

Who can participate in the clinical trial?

These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..

What medicines are being studied?

Medicines that are officially approved for use in the European Union and considered safe by EMA. These medicines are already on the market and may be tested for new conditions or populations.

Enbrel

Enbrel is a medicine that helps reduce immune system–caused inflammation to treat rheumatoid arthritis, psoriatic arthritis, and some types of psoriasis.

What active substances are being studied?

Active substances that are officially approved for use in the European Union and considered safe by EMA. These substances are already on the market and may be tested for new conditions or populations.

Abatacept

Abatacept is a substance that reduces immune system overactivity to treat autoimmune conditions such as rheumatoid arthritis.

Adalimumab

Adalimumab is a biologic that blocks a key inflammatory protein (TNF) to reduce inflammation in autoimmune conditions like rheumatoid arthritis and Crohn's disease.

Baricitinib

Baricitinib is a substance that reduces immune-driven inflammation to treat rheumatoid arthritis.

What similar medicines might you know?

Don't worry if you don't know the medicines tested in the trial. There is a chance you have heard about the similar medicines. Check the list below to see if you are familiar with any of them.

Benepali

Enbrel For Paediatric Use

Erelzi

Where is the clinical trial being conducted?

Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.

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Assistance Publique Hopitaux De Paris

Rheumatology

Angers, France

CHU Besancon

Rheumatology

Besançon, France

Centre Hospitalier Universitaire De Toulouse

Rheumatology

Blagnac, France

Sponsor: Les Hopitaux Universitaires De Strasbourg

Last updated: Nov 26, 2025

Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.